Bioinformatics Analyst

Company: Aequor Technologies LLC
Location: Cambridge
Posted on: May 23, 2023

Job Description:

Internal Title: Bioinformatics Analyst
Hybrid Position
2-3 days onsite
Multi-omics Bioinformatics Analyst

We are seeking a Bioinformatics Analyst to assist in multi-omics data analysis and setup network biology pipelines for supporting *** target discovery programs and indication prioritization efforts. The role involves analyzing large collections of bulk and single cell transcriptomic data, performing differential expression analysis and meta-analysis and interpret results using gene set enrichment analysis, network biology approaches and other relevant post-processing method, including machine learning based methods. It will also involve multi-omics data analysis (proteomics, epigenetics, genetic) and collaborating with a diverse team to integrate multi-omics evidence with other workstreams.

Scope :
" Review, format and ingest relevant differential expression results internally and publicly available
" Automate and improve transcriptomic analysis pipeline (differential expression meta-analysis, gene set enrichment...)
" Prototype innovative network biology and AI/Client methods for multi-omics analysis and make them production ready.
" Write and automate Rmarkdown or Rshiny reports
" Coordinate with the project team to integrate multi-omics evidence with other evidences workstreams

Skills :
" Experience with post-processing of transcriptomic differential expression results (GSEA, GSVA, meta-analysis...)
" Experience with network biology or AI/Client methods for bulk and pseudo-bulk transcriptomic and multi-omics (WGCNA, OmicsFold, autoencoders, etc).
" Good R programming skills
" HPC and cloud computing environments (AWS, GCP)
" Some experience in human genetic is preferred, e.g. GWAS summary statistics postprocessing, mendelian randomization, colocalization, polygenic scores..
" Very good communication and collaboration skills
" Minimum Education: Masters Degree

Keywords: Aequor Technologies LLC, Cambridge , Bioinformatics Analyst, Professions , Cambridge, Massachusetts