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Sr. Research Associate, Vector Production, AAV Engineering

Company: Voyager Therapeutics, Inc.
Location: Cambridge
Posted on: June 22, 2022

Job Description:

About VoyagerWe are Voyager Therapeutics, a pre-clinical stage biotech compelled by curiosity and powered by persistence. Voyagers are bold innovators who are energized in unlocking the full potential of AAV gene therapy employing our TRACER TM capsid discovery platform. Our resolve is to advance the field of AAV gene therapy, and through our innovative capsids, we are extending the reach and impact of our technology to help more patients in need.Recognizing that we can expand on the experience, innovation, and outcomes that propel our efforts by working together, we actively seek diverse views. If you're someone who wants to make discoveries that change the landscape of medicine for patients, we want you on our team!Job SummaryThe Vector Engineering team is generating a portfolio of designer AAV capsids with tailored properties, which could prove truly transformative for the future of gene therapy. We are looking for a talented and motivated Senior Research Associate to join the Novel Capsid Discovery group in order to expand our production capability for AAV libraries and research-grade AAV candidates for testing. The role will involve: 1) producing large-scale research-grade virus preparation for animal or cell culture studies 2) perform quality control, vialing, batch records and tracking of AAV preparations and 3) evaluate alternative methods to accelerate or improve the throughput, quality or reproducibility of virus preparations.As a Sr. Research Associate, you will work with fellow scientists in Novel Capsid Discovery to produce highly complex AAV libraries as well as individual library variants. You will apply standard vector production methods and help in optimization and development of new methods to increase our ability to produce high quality vectors at scale. You will be responsible for understanding the project goals and creatively optimizing solutions to ensure their success.Key Responsibilities

  • Maintain cultured cell lines
  • Large-scale preparation and sequencing plasmid DNA for AAV production
  • Production, purification and quality control of rAAV and AAV libraries
  • Help establish better systems for batch records, sorage and tracking of virus samples
  • Assist in lab logistics, keeping track of supplies and restocking
  • Follow lab and safety rulesQualifications
    • BA or MA in biology, biochemistry, biomedical engineering, or related fields
    • 5+ years hands-on wet lab experience
    • Highly skilled at mammalian cell culture:
      • Aseptic technique
      • Maintenance of cells in suspension or adherent conditions
      • Large-scale transfection
      • Experienced in large scale viral vector (preferably AAV) production, purification, titration, and transduction
      • Experienced in standard molecular biology techniques, such as PCR, gel electrophoresis and subcloning
      • Ability to conduct advanced procedures precisely and consistently
      • Ability to document and maintain an organized account of lab work and resultsPreferred Qualifications
        • Experience in AAV analytics techniques (ddPCR, DLS, PAGE electrophoresis, silver stain)
        • Sequence design and analysis software skills, such as Benchling and BLAST
        • 1+ years of industry experienceVoyager Therapeutics requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. Voyager Therapeutics will consider reasonable accommodations as required by federal, state, and local laws.

Keywords: Voyager Therapeutics, Inc., Cambridge , Sr. Research Associate, Vector Production, AAV Engineering, Professions , Cambridge, Massachusetts

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