Research Associate III: Viral Vector Production & Purification
Company: Broad Institute
Location: Cambridge
Posted on: February 22, 2021
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Job Description:
Research Associate III: Viral Vector Production & Purification
Cambridge, MA Job Description The Vector Engineering laboratory led
by Ben Deverman within the Stanley Center for Psychiatric Research
at the Broad Institute of Harvard and MIT is looking for
self-motivated research associates with experience producing and
purifying viral vectors and performing quality control assays. The
positions provide the opportunity to join a mission driven team
focused on expanding the impact of gene therapy by developing next
generation adeno-associated viruses (AAV). For examples of our
recent work, please see the references at the end of the job
description. The successful candidate will work closely with
members of the Vector Engineering team to support AAV production
and purification, high-throughput AAV screening, and the
development and implementation of quality control assays and
standard operating procedures. Successful candidates will also
contribute to collaborations with other Broad Institute scientists
and teams, and will be expected to function independently in
his/her daily responsibilities after training.-- CHARACTERISTIC
DUTIES Contribute to the design, implementation and troubleshooting
of experiments critical to the team's collective success Maintain
adherent and suspension cell lines and perform AAV production,
downstream processing, quantification and quality control assays--
Perform basic molecular biology experiments such as plasmid
construction, sequencing and QC assays, quantitative PCR, digital
droplet PCR, RNA, DNA and protein extractions from cell or tissue
samples, next generation sequencing (NGS) library preparation
Perform immunohistochemistry, reporter assays and FACS Consult
colleagues and the scientific literature, as needed, to support
ongoing and future projects Maintain meticulous records and
document, compile, and analyze experimental data Assist with
laboratory organization, ordering, and the operation and
maintenance of laboratory equipment, and perform other duties as
assigned Attend and contribute to team meetings-- Make
contributions to scientific manuscripts and conference
presentations REQUIREMENTS B.S. or M.S. with 3+ years of cell
culture experience in industry or academic vector core Hands-on
experience and extensive knowledge of mammalian cell culture,
transfection, and recombinant protein or virus production Upstream
and/or downstream process development for biologics (AAVs,
vaccines, mAb, or recombinant proteins) Experience performing a
variety of analytical assays Exceptional organizational and time
management skills, lab notebook practices and careful attention to
detail Outstanding interpersonal and communication skills Hands on
experience with any of the following is a plus:-- Stable cell line
generation and clonal analysis-- CRISPR/Cas9 and/or siRNA-based
gene knockout / knockdown Experience with common molecular biology
and cloning techniques (RNA/DNA isolation, restriction-ligation and
assembly based cloning, DNA sequencing and construct design).-- All
qualified applicants will receive consideration for employment
without regard to race, color, religion, sex, sexual orientation,
gender identity, national origin, disability or protected veteran
status. Check out this video for a look into our community! 0:00 /
1:42 Posted 2 Days Ago Full time 3428 About Us The Broad Institute
is pioneering a new model of collaborative biomedical science to
transform biology and medicine. To do that, we have created a
unique community of amazing, creative people - "Broadies" - each
with a passion for pushing scientific frontiers. Broadies have a
diverse collection of talents, expertise, and backgrounds, creating
a rich collaborative environment for solving intractable scientific
problems. We are always looking for new team members within
Research , Computational Biology , Software Engineering , and
Administration to help us tackle important problems at the cutting
edge of science. Why Broad? It comes down to our culture . Our
community transcends academic and organizational barriers,
encouraging different points of view and making all Broadies part
of something meaningful. If ours is a community you would want to
be a part of, then please apply!
Keywords: Broad Institute, Cambridge , Research Associate III: Viral Vector Production & Purification, Professions , Cambridge, Massachusetts
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