Scientist, RNA Synthesis

Company: Alnylam Pharmaceuticals
Location: Cambridge
Posted on: June 2, 2025

Job Description:

Overview
The RNA Synthesis team in Research group is seeking a passionate, creative scientist to join our highly interdisciplinary team focused on the advancement of our RNAi Platform and Lead Development efforts through novel approaches towards a deeper mechanistic/structural understanding of RNAi. The successful candidate will have a strong background in oligonucleotide chemistry/biochemistry through in-depth hands-on experience in the synthesis and chemical/biophysical characterization of oligonucleotides as well as their potential biological applications.This position is onsite and will be primarily located in Cambridge, MA. Key Responsibilities
* Design and execute the automated synthesis, purification, and analysis of siRNAs using state-of-the-art instrumentation platforms. Collaborate with internal biology and chemistry teams to enable a greater understanding of oligonucleotide or protein structure and siRNA activity
* Develop new and/or improved processes to expand upon current RNA synthesis capabilities
* Explore the role and impact of chemical modifications to improve various RNA-based or RNA-targeting modalities
* Troubleshoot and perform routine maintenance on critical instrumentation such as automated synthesis platforms, HPLC, and liquid handling robots
* Work closely with the members of Research & Development and participate in cross-functional internal meetings. Analyze, organize, and communicate data with key stakeholders in R&D and throughout the organization.Qualifications
* PhD in Chemistry, Biochemistry, or related discipline with 0-3 years post-degree experience in an industrial or academic setting
* Strong experience in solid-phase synthesis techniques (prior experience in RNA/DNA synthesis, peptide synthesis, oligosaccharide synthesis is preferred) is required
* Strong experience in bioconjugation techniques and knowledge in receptor-mediated delivery strategies is preferred
* Strong laboratory skills and experience with analytical instrumentation such as HPLC, LC-MS, etc. with the ability to analyze, interpret, and clearly present data
* The ability to apply his/her knowledge to a new area of study as well as to thrive in a highly interdisciplinary team environment with excellent oral and written communication skills
* Great team player with a high degree of flexibility and motivation in a fast-paced work environment
About Alnylam:Alnylam Pharmaceuticals (Nasdaq: ALNY) has led the translation of RNA interference (RNAi) into a whole new class of innovative medicines with the potential to transform the lives of people afflicted with rare and more prevalent diseases. Based on Nobel Prize-winning science, RNAi therapeutics represent a powerful, clinically validated approach to treating diseases at their genetic source by "interfering" with mRNA that cause or contribute to disease. Since our founding in 2002, Alnylam has led the RNAi Revolution and continues to turn scientific possibility into reality.Our culture:Our people-first culture is guided by our core values: fiercely innovative, open culture, purposeful urgency, passion for excellence, and commitment to people, and these values influence how we work and the business decisions we make. Thanks to feedback from our employees over the years, we've been fortunate to be named a top employer around the world. Alnylam is extremely proud to have been recognized as the #1 Large Employer by Boston Globe Top Places to Work in 2023 for the third consecutive year, one of Science Magazine's Top Biopharma Employers, one of America's Most Responsible Companies for 2024 by Newsweek, a Fast Company Best Workplace for Innovators, and a Great Place to Work in Canada, France, Italy, Spain, Switzerland, and UK - among others.At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. We are dedicated to building an environment where employees can feel that they belong, can bring their authentic selves to work, and achieve to their full potential. By empowering employees to embrace their unique differences at work, our business grows stronger with advanced and original thinking, allowing us to bring groundbreaking medicines to patients. Qualified applicants will receive consideration for employment without regard to their race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, ethnicity, marital status, protected veteran status, disability, or any other characteristics prohibited by law. >

Keywords: Alnylam Pharmaceuticals, Cambridge , Scientist, RNA Synthesis, Other , Cambridge, Massachusetts