Principal Scientist, Modeling & Simulation RLT

Company: Novartis Farmac--utica
Location: Cambridge
Posted on: September 3, 2024

Job Description:

Principal Scientist, Modeling & Simulation RLTJob ID: REQ-10019028Aug 26, 2024Location: USASummaryPrincipal Scientist I/II, Radioligand Modeling & Simulation. This position will be located in Cambridge, MA and will not have the ability to be located remotely. About the role: We are seeking a translational or clinical modeler eager to accelerate radioligand discovery & development by facilitating rigorous decision making with modeling & simulation. You will work in a multi-disciplinary environment, with opportunities to engage in cross-functional initiatives. This role reports to a PK Sciences Translational Modeling team lead, in a group situated within Biomedical Research, the research engine of Novartis.Key Responsibilities

• Act as the Translational M&S representative on radioligand therapy programs, developing and executing modeling strategies, contributing to project team discussions, and guiding therapeutic design and dose selection decisions.
• Build and apply innovative QSP and physiologically based PK (PBPK) models along with dosimetry estimations to link RLT pharmacology, tissue biodistribution, mechanism(s) of action, and biological and clinical outcomes.
• Contribute to an integrated RLT modeling platform that bridges data and knowledge across preclinical species and patients, partnering with discovery project teams as well as the preclinical safety and pharmacometrics groups.
• Implement innovative quantitative approaches to advance the translational science for radiopharmaceuticals.
• Proactively seek opportunities to increase the impact and awareness of translational and clinical modeling through communications with internal and external audiences.Minimum Qualifications
• Ph.D. in biology, pharmaceutical sciences, bioengineering, biophysics, or a related field along with demonstrated expertise in radiobiology/nuclear medicine.
• 2-3 years plus related experience ideally in industry for Principal Scientist II level.
• Prior experience in pharmacokinetics and pharmacodynamics (PK/PD), quantitative systems pharmacology (QSP), and/or physiologically based PK (PBPK) modeling is preferred.
• Expert level proficiency in core modeling fundamentals is required, including scripting languages (e.g., MATLAB, R), construction of ordinary differential equation (ODE) models, parameter estimation, and data visualization.
• Demonstrated ability to communicate modeling results to a multidisciplinary audience to facilitate decision-making.
• Fluent in English (oral and written).This is a dual level posting. The final level and title of the offer role would be determined by the hiring team based on the skills, experience & capabilities required to perform the role at the level the role has been offered.Benefits and RewardsRead our handbook to learn about all the ways we'll help you thrive personally and professionally: Novartis Life HandbookCommitment to Diversity and InclusionNovartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.Why NovartisHelping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients' lives. Ready to create a brighter future together?Accessibility & Reasonable AccommodationsThe Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, please send an e-mail to us.reasonableaccommodations@novartis.com or call +1(877)395-2339.
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Keywords: Novartis Farmac--utica, Cambridge , Principal Scientist, Modeling & Simulation RLT, Other , Cambridge, Massachusetts