Principal Scientist - Computational Biologics

Company: Disability Solutions
Location: Cambridge
Posted on: September 1, 2024

Job Description:

Working with UsChallenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us .When you join BMS, you are joining a diverse, high-achieving team united by a common mission. The Discovery Biotherapeutics team at BMS seeks to understand the structure and function of complex molecules such as bispecific antibodies, antibody drug conjugates and endogenous proteins in order to optimize their utility as therapeutic agents. We collaborate with biology and translational scientists imbedded in the Thematic Research Centers in order to prosecute Targets and Biological pathways with disease modifying potential. By using a blend of internal and external technologies and capabilities, we work to discover and deliver first-in-class as well as best-in-class molecules that warrant clinical evaluation for patient benefit.Here, you'll get the chance to grow and thrive through opportunities that are uncommon in scale and scope. You'll pursue innovative ideas while advancing professionally alongside some of the brightest minds in biopharma.We are seeking a collaborative bioinformatics and machine learning scientist to join the Computational Design and Predictive Modeling team in Cambridge, MA . You will develop novel bioinformatics and machine learning solutions and apply them to next-generation sequencing (NGS) data to discover and characterize biotherapeutics. You will partner with both computational and bench scientists to design experiments, analyze data , and implement computational models and bioinformatics pipelines. This role provides the opportunity to work with subject matter experts on cross-functional teams to solve challenging problems in how we discover and engineer the next generation of biotherapeutics. Responsibilities

• Develop computational models to analyze and characterize antibody repertoire sequencing data to deliver insights on antibody characteristics that improve lead identification .
• Implement and deploy high-throughput and scalable bioinformatics pipelines that will expedite biologics discovery and design .
• Communicate scientific findings to collaborators and other stakeholders, propose follow-up actions with measurable scientific outcomes.
• Partner with project teams to develop bioinformatics & machine learning solutions for novel biotherapeutics. Basic Qualifications: Bachelor's Degree 8+ years of academic / industry experienceorMaster's Degree 6+ years of academic / industry experienceorPhD 4+ years of academic / industry experience Preferred Qualifications
  • PhD in bioinformatics, computer science, engineering, statistics, or similar with 4+ years of relevant industry experience.
  • In-depth experience analyzing NGS data including B-cell receptor and antibody repertoire sequencing data.
  • In-depth understanding of antibody sequence and structure.
  • Strong experience with commonly used bioinformatics methods and toolkits.
  • Experience with state-of-the-art AI & ML methods applied to biological sequence data (DNA, protein)
  • Hands-on experience with public omics, protein and immune repertoire datasets such as PDB, OAS, SAbDab .
  • Strong experience with scientific programming languages (Python, R) and data science libraries.
  • Proven track record of contributing to and helping advance multi-disciplinary team projects.
  • Ability to independently conduct scientific research, develop hypotheses and deliver solutions.
  • Excellent problem-solving skills and teamwork.
  • Strong communication , documentation, data presentation, and visualization skills. If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career. Uniquely Interesting Work, Life-changing CareersWith a single vision as inspiring as Transforming patients' lives through science--- , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.On-site Protocol BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role: Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function. BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com . Visit careers.bms.com/ eeo -accessibility to access our complete Equal Employment Opportunity statement. BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters. BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

Keywords: Disability Solutions, Cambridge , Principal Scientist - Computational Biologics, Other , Cambridge, Massachusetts