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Senior Scientist - DNA Encoded Library Screen (DEL)

Company: Disability Solutions
Location: Cambridge
Posted on: July 1, 2024

Job Description:

Working with UsChallenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us .BMS encompasses a broad range of disciplines to enable a robust pipeline of drug candidates aimed at serious diseases. Chemistry is a core capability in Small Molecule & Drug Discovery with innovative scientists working in medicinal chemistry, radiochemistry, analytical chemistry, and large-scale synthesis. Within SMDD our Lead Discovery and Optimization (LDO) team is responsible for high throughput screening, compound storage and distribution, primary assays to support discovery programs, and compound profiling to explore drug liabilities in vitro. LDO scientists discover and adopt cutting edge assay technologies that utilize state-of-the-art automation to drive speed and efficiency. Our Molecular Structure and Design team embraces novel approaches to computer-aided drug design, machine learning, and structural biology. The integration of these disciplines provides a seamless and highly interactive environment for discovery scientists to learn, develop, and innovate. Working in partnership with our disease area experts in the Thematic Research Centers provides an exciting pathway to discover and deliver medicines to patients in need.Lead Discovery & Optimization (LDO) is a dynamic organization that supports the entire drug discovery continuum (from lead identification to clinical candidate delivery) at Bristol Myers Squibb. The organization leverages state-of-the-art technologies, complemented by deep subject matter expertise and broad scientific knowledge, to deliver innovative and comprehensive preclinical in vitro datasets to support our drug discovery pipeline in disease areas such as cell therapy, oncology, immunology, neuroscience and cardiovascular diseases.We are seeking a highly motivated scientist to design and execute DNA Encoded library Screen (DEL) selections to identify small molecule ligands to support drug discovery programs across the BMS Portfolio. This individual will work independently while being a part of a larger team to drive innovative solutions for next-generation DEL, including the development and improvement of affinity selection techniques. The candidate will collaborate with multidisciplinary science teams, such as therapeutic area representatives, protein sciences, high-throughput screening, and chemistry, to ensure project alignment. The candidate should have the ability to understand diverse target biology and utilize a spectrum of biochemical techniques to prepare DEL libraries for screening, develop protein immobilization and selection methods, and engage in next-generation sequencing. The ideal candidate will have demonstrated experience analyzing large datasets and effectively communicating results to broad project teams. This is a hands-on laboratory-based position. Duties/Responsibilities:

  • Accountable for developing DEL workflows and coordinating the selection efforts to support drug discovery programs across the BMS Portfolio
  • Lead efforts to identify, evaluate, and implement new technologies in the DNA encoded library space and push the boundaries to adapt next-gen DEL technologies
  • Interact closely with disease biology colleagues, protein science and chemistry to effectively drive cross-functional collaboration on DNA-encoded library selection
  • Interface with the Chemoinformatics team to oversee DEL library informatics, NGS and hit analysis.
  • Analyze, interpret, and effectively report hit report data at team meetings.
  • Work with external partners to effectively drive collaboration Basic Qualifications Bachelor's Degree 7+ years of academic/industry experienceorMaster's Degree 5+ years of academic/industry experienceorPhD 2+ years of academic / industry experience Preferred Qualifications:
    • Ph.D. in Biochemistry, Chemistry, or Molecular biology with 2+ years of proven laboratory experience in the pharmaceutical or biotech industry
      • Hands-on experience with affinity selections such as DEL, phage and mRNA display
      • A strong desire to innovate and expand DEL technology beyond the current landscape
      • Proficient in molecular biology techniques, such as PCR, qPCR, and NGS
      • Familiarity with the analysis and visualization of large datasets, particularly with DataWarrior, Spotfire or equivalent
      • Knowledge of protein sciences and biophysical techniques such as TSA and SPR is an advantage.
      • Experience in small molecule drug discovery, particularly cell-based assay development, is a plus
      • Motivated, independent, creative, and productive problem solver with a proven ability to advance new scientific concepts.
      • Excellent written and verbal communication skills, as well as organizational skills If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career. Uniquely Interesting Work, Life-changing CareersWith a single vision as inspiring as Transforming patients' lives through science--- , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.On-site Protocol BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role: Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function. BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com . Visit careers.bms.com/ eeo -accessibility to access our complete Equal Employment Opportunity statement. BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters. BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

Keywords: Disability Solutions, Cambridge , Senior Scientist - DNA Encoded Library Screen (DEL), Other , Cambridge, Massachusetts

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