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Senior Scientist, Genetics IPS

Company: Disability Solutions
Location: Cambridge
Posted on: March 30, 2024

Job Description:

Working with UsChallenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: you join BMS, you are joining a diverse, high-achieving team united by a common mission.--The Informatics and Predictive Sciences (IPS) mission is to Pioneer, Partner and Predict to drive transformative insights for patient benefit. --IPS conducts applied computational research in areas that include genomic, structural and molecular informatics, computational and systems biology, patient selection and translational biomarker research, and broader fields including knowledge science, epidemiology and machine learning-across the full lifecycle of drug discovery and development and across all therapeutic areas at BMS. We do this in close partnership with scientific and clinical experts in the field, both inside and outside the company.--- --We perform innovative science to empower key data-driven decisions across a rich pipeline of next-generation medicines. In doing so, our work transforms the lives of patients, as well as our own lives and careers.Here, you'll get the chance to grow and thrive through opportunities that are uncommon in scale and scope. You'll pursue innovative ideas while advancing professionally alongside some of the brightest minds in biopharma.Senior Scientist, Genetics IPSAt Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science.--In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.We seek a talented computational researcher to use large biobank datasets to identify genetically-defined patient populations that match novel target mechanisms. This role will sit within Informatics & Predictive Sciences, a globaly distributed group driving innovative computational research for discovery and early development within BMS research.A key focus will be to identify genetic markers that define patient sets with a higher probability of successful response to newly discovered BMS targets/therapeutics. This will involve the application of advanced computational approaches in statistical genetics and predictive modeling (e.g. polygenic modeling, rare variant burden tests, disease trajectory analyses) to biobank and other human genetics datasets. It will also include close coordination with discovery and clinical program teams to enable these scientific insights to have meaningful impact on our ability to deliver novel therapies that address unmet medical need. --------This position offers an exciting opportunity to impact human health through innovative human genomics research, and will enable discovery groups within BMS research to launch novel programs based on causal human biology. It is also an opportunity to work closely with the broader scientific community through pre-competitive collaborations (e.g. FinnGen, UK Biobank, UK Genes & Health), and to publish and present industry-leading work in this area. --Location: Cambridge, MAResponsibilities will include, but are not limited to, the following:

  • Design and perform statistical analyses in biobank / real-world data sets that match drug mechanisms to specific patient populations (e.g. with polygenic scores and rare variants)
  • Design and perform analyses of genetic analysis of disease progression with longitudinal clinical data
  • Contribute to efforts to build capabilities for integrative analyses across a suite of biobank data resources
  • Coordinate with stakeholders across research and clinical to facilitate the use of germline genetics and related biomarkers in future clinical trials
  • Communicate findings and recommend follow up actions in multiple settings (including 1:1, seminars, project meetings, and external publications)Basic Qualifications:Bachelor's Degree and 7+ years of academic or industry experienceorMaster's Degeree and 5+ years of academic or industry experienceorPh.D and 2+ years of academic or industry experience--Preferred Qualifications: The ideal candidate will have the following mix of professional and personal characteristics:
    • PhD with training in population/statistical genetics or a related computational/quantitative discipline field
    • Experience applying genetics to drug development and/or other healthcare-related applications
    • A minimum of or more years relevant research experience, preferred
    • Deep scientific expertise in population and statistical genetics, including polygenic models and analyses of rare variants (e.g. long-standing working experience in this area and/or a track record of high-impact peer-reviewed publications)
    • Advanced hands-on knowledge of at least one high-level programming language such as R or Python
    • Demonstrated ability to advance multi-disciplinary team projects requiredIf you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.Uniquely Interesting Work, Life-changing CareersWith a single vision as inspiring as "Transforming patients' lives through science--- ", every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.On-site ProtocolBMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to Visit to access our complete Equal Employment Opportunity statement.BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

Keywords: Disability Solutions, Cambridge , Senior Scientist, Genetics IPS, Other , Cambridge, Massachusetts

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