Scientist Computational Structural Biology

Company: Sanofi
Location: Cambridge
Posted on: November 15, 2023

Job Description:

Job Description

We seek a highly motivated scientist to join our Structural Biology & Protein Design (SBPD) Lab at Sanofi. Our SBPD Lab is a part of the Protein Engineering Group within the LMR (Large Molecule Research) Department. As a key member of our highly efficient and dynamic team, you will deliver structural biology results and structure-based protein engineering solutions to contribute to exciting biologics projects from Immuno-oncology, Immunology & Inflammation and Rare & Neuro therapeutic areas. Our success will be enabled by Sanofi's on-site, state-of-art cryo-EM facility and rapid adoption of leading-edge digital biology tools used. The successful candidate will work in a collaborative, multidisciplinary and fast-paced work environment to design and engineer revolutionary large molecule medicines, including multivalent, multi-targeting antibodies/nanobodies/fusion proteins. This is an exciting and unique opportunity to play a key role in resolving real-world challenges within biologics drug discovery and make impacts to patients' life.

Key Responsibilities

• Deliver and present structural biology and structure-based analysis to support large molecule projects.
• Structure and protein engineering support for Sanofi's biologics R&D portfolio, making full use of our newly established top-end cryo-EM infrastructure.
• Develop and integrate modeling, computational and structural biology methods to provide protein design solutions for antibody/nanobody engineering, including affinity modification, cross-reactivity engineering, liability risk prediction and mitigation, multi-specific antibody engineering, etc.
• Closely monitor leading edge developments in scientific literatures and develop new skills in the area of structural biology and antibody engineering.
• Effectively collaborate with colleagues from diverse scientific backgrounds. Basic Qualifications
  • PhD in Biochemistry, Biophysics, or similar, OR MS with 3 years of experience in structural biology and protein design . Hands-on expertise with all aspects of protein crystallography and cryo-EM.
  • Deep understanding of antibody/nanobody structure and the application of structure within biologics R&D. Hands-on experience with protein modeling, structural analysis, structure-based protein design and optimization of biochemical and biophysical properties using computational protein design tools.
  • A drive for self-development with a focus on scientific know-how. Excellent problem solving and written/oral communication skills, as well as scientific writing, presentation, and collaboration skills.
  • Track record of scientific accomplishments as evidenced by a strong publication record.
  • Success to obtain high resolution structures of integral membrane proteins is preferred.
  • Familiarity with statistics and machine learning is preferred. Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.
    
    At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.
    
    

Keywords: Sanofi, Cambridge , Scientist Computational Structural Biology, Other , Cambridge, Massachusetts