Senior or Principal Scientist DMPK

Company: Sanofi
Location: Cambridge
Posted on: September 19, 2023

Job Description:

Sanofi is seeking an experienced scientist to join the Drug Metabolism and Pharmacokinetics (DMPK) research platform of the North American Hub. This role is based in Cambridge and will be a hybrid role that allows for both on-site and remote work.Key Responsibilities

• Represent DMPK on preclinical development projects to ensure effective integration of DMPK science into the company's strategy of developing first and best in class therapies for Oncology, Inflammatory and Rare/Neurological diseases
• Contribute to the project team strategy at the early discovery phase up to first in human (FIH) trials
• Characterize ADME and PK properties of small molecules, biologics, and/or gene therapies
• Conceive and implement the preclinical strategy for predicting human efficacious and safe starting dose levels for first in human clinical trials
• Support the DMPK organization by conceiving and executing studies (either internally or externally) to address critical knowledge gaps
• Contribute to the writing and submission of regulatory documentsRequirements
  • Ph.D. in Pharmacology, Drug Metabolism, Biochemistry, Molecular Biology, Pharmacokinetics or other relevant field with a minimum of 5 years of relevant experience, OR Master's degree and 7 years of relevant experience, OR Bachelor's and 10 years of relevant experience---.
  • Ability to drive and lead ADME and PKPD strategies for discovery project teams
  • Ability to function in a matrix environment and communicate with a diverse set of ever-changing individuals is a must
  • Strong written, presentation, and verbal communication skills
  • Ability to conduct, interpret, and communicate non-compartmental analysis (NCA) for non-regulated PK and TK reports is a plus
  • Ability to conduct quantitative PKPD analysis is a plus; ability to think about drug discovery through a PKPD lens is a must
  • Experience with the non-clinical development of nucleic acid-based therapies is a plus
  • Experience with the preparation of documents for regulatory submission (IND/IMPD/CTX) is a plusSanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.#GD-SA -#LI-SAAt Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.

Keywords: Sanofi, Cambridge , Senior or Principal Scientist DMPK, Other , Cambridge, Massachusetts