Senior or Principal Scientist DMPK
Company: Sanofi
Location: Cambridge
Posted on: September 19, 2023
Job Description:
Sanofi is seeking an experienced scientist to join the Drug
Metabolism and Pharmacokinetics (DMPK) research platform of the
North American Hub. This role is based in Cambridge and will be a
hybrid role that allows for both on-site and remote work.Key
Responsibilities
- Represent DMPK on preclinical development projects to ensure
effective integration of DMPK science into the company's strategy
of developing first and best in class therapies for Oncology,
Inflammatory and Rare/Neurological diseases
- Contribute to the project team strategy at the early discovery
phase up to first in human (FIH) trials
- Characterize ADME and PK properties of small molecules,
biologics, and/or gene therapies
- Conceive and implement the preclinical strategy for predicting
human efficacious and safe starting dose levels for first in human
clinical trials
- Support the DMPK organization by conceiving and executing
studies (either internally or externally) to address critical
knowledge gaps
- Contribute to the writing and submission of regulatory
documentsRequirements
- Ph.D. in Pharmacology, Drug Metabolism, Biochemistry, Molecular
Biology, Pharmacokinetics or other relevant field with a minimum of
5 years of relevant experience, OR Master's degree and 7 years of
relevant experience, OR Bachelor's and 10 years of relevant
experience---.
- Ability to drive and lead ADME and PKPD strategies for
discovery project teams
- Ability to function in a matrix environment and communicate
with a diverse set of ever-changing individuals is a must
- Strong written, presentation, and verbal communication
skills
- Ability to conduct, interpret, and communicate
non-compartmental analysis (NCA) for non-regulated PK and TK
reports is a plus
- Ability to conduct quantitative PKPD analysis is a plus;
ability to think about drug discovery through a PKPD lens is a
must
- Experience with the non-clinical development of nucleic
acid-based therapies is a plus
- Experience with the preparation of documents for regulatory
submission (IND/IMPD/CTX) is a plusSanofi Inc. and its U.S.
affiliates are Equal Opportunity and Affirmative Action employers
committed to a culturally diverse workforce. All qualified
applicants will receive consideration for employment without regard
to race; color; creed; religion; national origin; age; ancestry;
nationality; marital, domestic partnership or civil union status;
sex, gender, gender identity or expression; affectional or sexual
orientation; disability; veteran or military status or liability
for military status; domestic violence victim status; atypical
cellular or blood trait; genetic information (including the refusal
to submit to genetic testing) or any other characteristic protected
by law.#GD-SA -#LI-SAAt Sanofi diversity and inclusion is
foundational to how we operate and embedded in our Core Values. We
recognize to truly tap into the richness diversity brings we must
lead with inclusion and have a workplace where those differences
can thrive and be leveraged to empower the lives of our colleagues,
patients and customers. We respect and celebrate the diversity of
our people, their backgrounds and experiences and provide equal
opportunity for all.
Keywords: Sanofi, Cambridge , Senior or Principal Scientist DMPK, Other , Cambridge, Massachusetts
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