Senior RA/Associate Scientist, In Vivo Pharmacology

Company: THIRD ROCK VENTURES, LLC
Location: Cambridge
Posted on: May 28, 2023

Job Description:

Senior RA/Associate Scientist, In Vivo Pharmacology at Fulcrum Therapeutics * Fulcrum requires all employees to be fully vaccinated against COVID-19. This requirement is a condition of employment at Fulcrum, and it applies regardless of whether or not the position is located onsite at Fulcrum's headquarters in Cambridge, MA. If you are unable to receive the vaccine due to a serious medical condition, or because it is prohibited as a result of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation. Company Overview Fulcrum Therapeutics is a clinical-stage biopharmaceutical company focused on improving the lives of patients with genetically defined rare diseases in areas of high unmet medical need. Fulcrum's two lead programs in clinical development are losmapimod, a small molecule for the treatment of facioscapulohumeral muscular dystrophy (FSHD) and FTX-6058, a small molecule designed to increase expression of fetal hemoglobin for the treatment of sickle cell disease and other hemoglobinopathies, including beta-thalassemia. The company's proprietary product engine, FulcrumSeekTM, identifies drug targets that can modulate gene expression to treat the known root cause of gene mis-expression. Description As a member of the pharmacology team at Fulcrum Therapeutics, this role will be responsible for the design and execution of mechanistic in vivo and ex-vivo pharmacology research projects in research areas such as genetically defined hematological, musculoskeletal, and other rare disorders. The candidate will be part of a multi-disciplinary team to conduct experiments aimed at building relationships between in vitro cellular assays and in vivo/ ex-vivo PK/PD, target engagement, and efficacy of potential drug candidates to drive drug discovery. We seek an innovative scientist who is looking to be part of a dynamic team, open to new challenges and excited to have a direct impact on the discovery and development of novel therapies for patients living with rare diseases. Responsibilities

• Responsible for independently conducting in vivo studies with rodents in accordance with IACUC requirements.
• Contribute to study designs, planning and performing in vivo studies related to PK/PD and efficacy studies from early exploratory to IND stage.
• Provide analysis and interpretation of data with clear communication in cross-functional team meetings.
• Perform routine rodent handling and dosing independently by various routes (e.g., oral gavage, IP, IV, SC, IM)
• Perform blood draws, necropsies, and process ex vivo samples.
• Conduct assays for ex vivo target engagement and biomarker analysis from tissue and blood samples to understand the mechanism of action of various therapeutic agents.
• Ability to conduct in vitro assays, gene expression analysis, protein analysis and general molecular biology techniques is a plus.
• Demonstrate independent thought/creativity in science with excellent collaboration and communication across functional disciplines, multitasking skills and able to present work formally to scientific research committees.
• Maintain accurate, timely and complete electronic laboratory notebook entries. Qualifications
  • BS or MS with relevant experience in areas related to Cell Biology, Molecular Biology and/or Pharmacology in an academic or industry setting.
  • Proven track record of performing in vivo experiments in rodents, including handling, dosing and necropsy.
  • Hands-on experience with a range of in vitro/ ex vivo techniques (such as RNA/DNA extraction, qPCR, ELISA, protein analysis via Western blot, WES, and/or MSD) is desirable.
  • Experience running flow, ICC, FISH, and/or IHC imaging assays is a plus.
  • Demonstrated ability to execute experiments, analyze data and report conclusions.
  • Passionate about contributing to the team in a diverse and inclusive environment every day, in- and outside the lab.
  • Ability to thrive in a highly collaborative, fast-paces, team-oriented environment with diverse disciplines.
  • Outstanding interpersonal and communication (written and verbal) skills; demonstrates calm, professional, diplomatic, and positive behaviors.

Keywords: THIRD ROCK VENTURES, LLC, Cambridge , Senior RA/Associate Scientist, In Vivo Pharmacology, Other , Cambridge, Massachusetts