Associate Scientist-iPSCs

Company: Integrated Resources, Inc
Location: Cambridge
Posted on: May 24, 2023

Job Description:

Job Description: Senior Associate Scientist, Neuroscience Discovery Biology
(100% on-site)

*** seeks a highly motivated Associate Scientist to join the Stem Cell and Disease Modeling team in the Neuroscience Thematic Research Center (NTRC). The newly developed NTRC is dedicated to the discovery of new treatments for neurodegenerative diseases such as Alzheimers and Parkinsons disease as well as rare diseases that affect both adults and children. We are looking for a candidate who is passionate about stem cell research and discovery of new medicines for neurodegeneration and who appreciates the challenges and rewards in this field.

Responsibilities

Perform cell culture (iPSCs, primary cells, immortalized cell lines) to support the research needs of the group
Differentiate iPSCs to specialized CNS cell types
Develop disease-relevant assays with iPSC-derived cells to drive target validation & drug discovery efforts
Develop image-based high-content screening assays to capture disease-relevant phenotypes
Organizes and maintains experimental data in lab notebook
Participates in troubleshooting of routine experiments

Requirements

B.S with 4+ years or MS with 2+ years of experience in Biology, Molecular Biology related fields in industry or academic setting
Requires a good understanding and practical experience in routine mammalian cell culture and microscopy
Experience with molecular biology techniques such as western blotting, immunostaining, DNA & RNA extractions, and qPCR
Works under minimal supervision for routine activities and moderate supervision for non-routine activities
Fast learner who can independently conduct experiments following established protocols and can develop new techniques
Excellent communication, organizational and time management skills, adaptable and ability to multitask
Ability to work effectively with others in a collaborative team environment

Preferred Additional Qualifications and Experience

Significant cell culture experience with cell lines, primary cells
Experience with iPSC differentiation to a variety of specialized neurons and subsequent characterization of iPSC-neurons
Experience with high throughput cell biology including high content imaging, signal transduction assays or genetic screens
Genome editing, CRISPR engineering, RNAi approaches.
Ability to learn and become independent to drive assay development efforts

Keywords: Integrated Resources, Inc, Cambridge , Associate Scientist-iPSCs, Other , Cambridge, Massachusetts