Sr. Scientist OR Principal Scientist - Drug Metabolism and Pharmacokinetics

Company: Sanofi
Location: Cambridge
Posted on: March 20, 2023

Job Description:

Sanofi is seeking a scientist to join the Drug Metabolism and Pharmacokinetics (DMPK) research platform of the North American Hub. This role is based in Cambridge and will be a hybrid role that allows for both on-site and remote work.

Key Responsibilities

• Represent DMPK on preclinical development projects to ensure effective integration of DMPK science into the company's strategy of developing first and best in class therapies for Oncology, Inflammatory and Rare/Neurological diseases.
• Contribute to the project team strategy at the early discovery phase up to first in human (FIH) trials
• Characterize ADME and PK properties of small molecules, biologics, and/or gene therapies
• Conceive and implement the preclinical strategy for predicting human efficacious and safe starting dose levels for first in human clinical trials
• Provide scientific oversight and operational support (aid in outsourcing, study design, and data interpretation) for non-GLP pharmacokinetic (PK) and toxicokinetic (TK) studies.
• Perform non-compartmental analysis (NCA) and write PK and TK reports for non-GLP studies.
• Contribute to the writing and submission of regulatory documents. Requirements
  • Ph.D. in Pharmacology, Drug Metabolism, Biochemistry, Molecular Biology, Pharmacokinetics or other relevant field with a minimum of 3 years of relevant experience, OR Master's degree and 5 years of relevant experience, OR Bachelor's and 8 years of relevant experience .
  • Ability to drive and lead ADME and PKPD strategies for discovery project teams
  • The ability to function in a matrix environment and communicate with a diverse set of ever-changing individuals is a must
  • Strong written, presentation and verbal communication skills
  • Ability to conduct non-compartmental analysis (NCA) for non-regulated PK and TK reports is a must
  • Ability to conduct PKPD analysis is a plus
  • Experience with the preparation of documents for regulatory submission (IND/IMPD/CTX) is a plus At Sanofi R&D North America, we deliver meaningful solutions for patients. We transform science into breakthrough, best-in-class and first-in-class medicines and vaccines. We believe in creating a diverse and inclusive workforce - and workplace - which brings together the collective brainpower of over 2,000 colleagues and provides you with an exciting place to grow and develop. We set the bar high, and we deliver. Join us and together we will build on our trusted legacy of breakthroughs for society.
    
    Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.
    
    As a healthcare company and a vaccine manufacturer, Sanofi has an important responsibility to protect individual and public health. All US based roles require individuals to be fully vaccinated against COVID-19 as part of your job responsibilities.
    
    According to the CDC, an individual is considered to be "fully vaccinated" fourteen (14) days after receiving (a) the second dose of the Moderna or Pfizer vaccine, or (b) the single dose of the J&J vaccine. Fully vaccinated, for new Sanofi employees, is to be fully vaccinated 14 DAYS PRIOR TO START DATE.
    
    At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.
    
    

Keywords: Sanofi, Cambridge , Sr. Scientist OR Principal Scientist - Drug Metabolism and Pharmacokinetics, Other , Cambridge, Massachusetts