Head of Chemistry

Company: GlaxoSmithKline
Location: Cambridge
Posted on: March 18, 2023

Job Description:

Head of Oligo Platform Chemistry page is loaded Head of Oligo Platform Chemistry Apply locations USA - Massachusetts - Cambridge time type Full time posted on Posted Today job requisition id 365075 About the Role If you want to be part of a collaborative and focused team with a mission to build GSK's new therapeutic oligo platform, please apply! We are seeking an experienced Head of Oligo Platform Chemistry to lead the chemistry efforts. This is an exciting opportunity to build a capability and team from the ground up within GSK's Medicines Design organization. The successful candidate will lead GSK's RNA therapeutic chemical design strategy, exploration of new oligo chemistries and its implementation in drug discovery programs. You will be responsible for establishing the strategy, infrastructure, and internal capability to realize GSK's future RNA therapeutic ambitions. This role requires in-depth knowledge therapeutic oligonucleotide drug development from Target Validation through to pre-clinical development. The responsibilities for this role are the following:

• Leading the oligo chemistry team and working effectively within cross-functional discovery and development organizations, to advance the preclinical portfolio.
• Provide scientific leadership for the design and synthesis of oligonucleotides and oligonucleotide bioconjugates, as well as analysis of structure-activity relationships.
• Lead the efforts to develop and enable new oligonucleotide chemistries in collaboration with the medicinal chemistry and CMC organizations
• Lead the exploration of novel delivery platforms for effective delivery of RNA/oligonucleotides using innovative bioconjugation strategies. Conceive and execute scientific strategies for extrahepatic delivery platforms.
• Accountable for understanding the external landscape for therapeutics oligonucleotides as well as competitor approaches to oligonucleotide discovery and development.
• Initiate and lead the evaluation of external and internal capabilities and facilitate collaborations with external partners.
• Manage, coach, and develop a high performing team and building an oligo chemistry capability in GSK.
• Strong organizational leadership skills with a proven track record in setting vision/strategy and managing team execution to achieve key company milestones Why You?
  Basic Qualifications: We are looking for professionals with these required skills to achieve our goals:
  • PhD in Chemistry, Bioorganic Chemistry, or related field with 10+ years of experience in oligonucleotide therapeutics or pharmaceutical industry preferred.
  • Deep understanding of modern methods in synthetic chemistry with an emphasis on nucleosides, nucleotides and oligonucleotide synthesis, along with purification and analytical characterization as applied to nucleic acid therapeutics
  • Knowledge and experience with oligonucleotide conjugation chemistries
  • Track record of successful leadership, including training, developing, and managing talent.
  • Proven ability to build, motivate and inspire high performing teams, as well as effectively collaborate with cross-functional teams.
  • Demonstrated effective organizational skills, including ability to set, prioritize and achieve research goals.
  • Solid strategic thinking and excellent communication skills for developing/articulating program strategy, risk mitigation plans, and milestones Preferred Qualifications & Skills: If you have the following characteristics, it would be a plus:
    • Working knowledge of RNA biology and oligonucleotide screening technologies to facilitate effective team collaboration
    • Strong organic chemistry expertise with excellent track record of solving synthetic challenges
    • Strong scientific and analytical skills. Demonstrated ability to multitask efficiently, prioritize quickly and bring projects to conclusion.
    • Ability to matrix with a team of multi-discipline experts including biology, chemistry, safety assessment, computational sciences, clinical scientists, translational scientists, and others.
      • Demonstrated effective communication and negotiation skills for a wide variety of audiences, including laboratory analysts and senior management.#LI-GSKGSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive. Getting ahead means preventing disease as well as treating it, and we aim to impact the health of 2.5 billion people around the world in the next 10 years.Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a workplace where everyone can feel a sense of belonging and thrive as set out in our Equal and Inclusive Treatment of Employees policy. We're committed to being more proactive at all levels so that our workforce reflects the communities we work and hire in, and our GSK leadership reflects our GSK workforce.If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.At GSK, the health and safety of our employees are of paramount importance. As a science-led healthcare company on a mission to get ahead of disease together, we believe that supporting vaccination against COVID-19 is the single best thing we can do in the US to ensure the health and safety of our employees, complementary workers, workplaces, customers, consumers, communities, and the patients we serve. -GSK has made the decision to require all US employees to be fully vaccinated against COVID-19, where allowed by state or local law and where vaccine supply is readily available. The only exceptions to this requirement are employees who are approved for an accommodation for religious, medical or disability-related reasons.Important notice to Employment businesses/ AgenciesGSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting For the Record site. Similar Jobs (4) Head of Oligo Platform Biology locations USA - Massachusetts - Cambridge time type Full time posted on Posted Today Head of Oligo Platform Design and Informatics locations USA - Massachusetts - Cambridge time type Full time posted on Posted Today About Us We are a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive. Getting ahead means preventing disease as well as treating it, and we aim to impact the health of 2.5 billion people around the world in the next 10 years.Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves - feeling welcome, valued and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together. Find out more on our career site .

Keywords: GlaxoSmithKline, Cambridge , Head of Chemistry, Other , Cambridge, Massachusetts