Senior Principal Scientist, Computational and Systems Biology
Company: Bristol Myers Squibb
Location: Cambridge
Posted on: March 18, 2023
Job Description:
Working with UsChallenging. Meaningful. Life-changing. Those
aren't words that are usually associated with a job. But working at
Bristol Myers Squibb is anything but usual. Here, uniquely
interesting work happens every day, in every department. From
optimizing a production line to the latest breakthroughs in cell
therapy, this is work that transforms the lives of patients, and
the careers of those who do it. You'll get the chance to grow and
thrive through opportunities uncommon in scale and scope, alongside
high-achieving teams rich in diversity. Take your career farther
than you thought possible.Bristol Myers Squibb recognizes the
importance of balance and flexibility in our work environment. We
offer a wide variety of competitive benefits, services and programs
that provide our employees with the resources to pursue their
goals, both at work and in their personal lives. Read more: We seek
a collaborative and highly innovative computational scientist to
join our Predictive Sciences team to work on multi-omics
perturbation data from compounds in our proprietary library to
infer novel mechanism-of-action (MoA) and help build models,
facilitating the design of new compounds with desired MoA.This
position will work alongside biology and chemistry colleagues and
other global Informatics and Predictive Sciences (IPS) teams. The
successful applicant will play a key scientific role in analyzing
screening data from our compound library to infer their MoA and
therapeutic effects on specific disease subtypes. This candidate
will also work on developing methods to deepen our understanding of
additional protein degradation machinery and work with the
chemistry team to incorporate these findings to expand our compound
library. This candidate will collaborate extensively with the
machine learning and chemoinformatic team to build generative and
predictive models to identify rules to design compounds with
desired therapeutic effects. We seek a meticulous and scrupulous
candidate passionate about learning a new drug discovery paradigm,
bringing new medicines to the patients, and comfortable working in
a fast-paced and highly collaborative environment.Responsibilities
-
- Interrogate multi-dimensional compound profiling data from
proteomics, transcriptomics, and phenomics screens to characterize
compounds' MoA.
- Use the compound's MoA to infer their therapeutic effects on
specific disease sub-types and design experiments to validate their
efficacy in the relevant pre-clinical models. -
- Work with other members of the Predictive Sciences team to
nominate high-value targets and interrogate our compound library to
identify compounds downmodulating them.
- Develop methods to interrogate and deepen our understanding
around additional mechanisms to degrade proteins and devise
experimental strategies to validate it.
- Devise screening strategies, guide screen execution, and
develop corresponding data analytics
- Collaborate with the machine learning team to design de novo
molecules with desirable MoA profiles using generative AI
approaches. - -
- Work with informatics and compound management team to manage
compound screen and high throughput assay datasets. -
- Associate MoA classes of a compound library to its chemical
features to elucidate Structure-Activity Relationships. -
- Collaborate with internal and external partners to plan and
execute various screening and validation strategies for drug
discovery programs. -
- Author scientific reports and present methods, results, and
conclusions to a publishable standard.Basic Qualifications
- Bachelor's Degree in computational biology, or systems biology
with 10+ years of academic / industry experience and 2+ years of
leadership experience.
- OR Master's Degree in computational biology, or systems biology
with 8+ years of academic / industry experience and 2+ years of
leadership experience.
- OR PhD in computational biology, or systems biology with 6+
years of academic / industry experience and 2+ years of leadership
experience.Preferred Qualifications
- Ph.D. in computational biology, or systems biology with 8+
years of post-doctoral experience in applying computational and
analytical approaches in university, pharma, or biotech settings,
focusing on drug discovery or elucidating underlying disease
pathology. -
- Working knowledge of drug discovery in pre-clinical or
early-phase drug development using screening data from various
high-throughput omics platforms.
- Strong expertise in unsupervised machine learning and pattern
recognition. -
- Ability to analyze and interpret data from multiple
experimental assays and propose new biological hypotheses. - -
- Demonstrated cross-discipline collaborations, particularly with
chemo-informatics, machine learning, and wet-lab scientists. -
-
- Strong scientific understanding of molecular biology,
preferably in Oncology. -
- Expertise in programming and scripting languages (R, Python, or
Matlab). -
- Strong applied statistical background. -
- Proven problem-solving skills and ability to work
independently. - -
- Excellent verbal and written communication skills. -The
starting compensation for this job -is a range from
$159,000-$185,000, plus incentive cash and stock opportunities
(based on eligibility).The starting pay rate takes into account
characteristics of the job, such as required skills and the where
the job is performed.Final individual compensation will be decided
-based on demonstrated -experience. -For more on benefits, please
visit our . Eligibility for specific benefits listed on our BMS
Careers site may vary based on the job and location.If you come
across a role that intrigues you but doesn't perfectly line up with
your resume, we encourage you to apply anyway. You could be one
step away from work that will transform your life and
career.Uniquely Interesting Work, Life-changing CareersWith a
single vision as inspiring as "Transforming patients' lives through
science--- ", every BMS employee plays an integral role in work
that goes far beyond ordinary. Each of us is empowered to apply our
individual talents and unique perspectives in an inclusive culture,
promoting diversity in clinical trials, while our shared values of
passion, innovation, urgency, accountability, inclusion and
integrity bring out the highest potential of each of our
colleagues.On-site ProtocolPhysical presence at the BMS worksite or
physical presence in the field is a necessary job function of this
role, which the Company deems critical to collaboration,
innovation, productivity, employee well-being and engagement, and
it enhances the Company culture.COVID-19 InformationTo protect the
safety of our workforce, customers, patients and communities, the
policy of the Company requires all employees and workers in the
U.S. and Puerto Rico to be fully vaccinated against COVID-19,
unless they have received an exception based on an approved request
for a medical or religious reasonable accommodation. -Therefore,
all BMS applicants seeking a role located in the U.S. and Puerto
Rico must confirm that they have already received or are willing to
receive the full COVID-19 vaccination by their start date as a
qualification of the role and condition of employment. -This
requirement is subject to state and local law restrictions and may
not be applicable to employees working in certain jurisdictions
such as Montana. This requirement is also subject to discussions
with collective bargaining representatives in the U.S.BMS is
dedicated to ensuring that people with disabilities can perform
complex functions through a transparent recruitment process,
reasonable workplace adjustments and ongoing support in their
roles. Applicants can request an accommodation prior to accepting a
job offer. If you require reasonable accommodation in completing
this application, or in any part of the recruitment process, direct
your inquiries to . Visit to access our complete Equal Employment
Opportunity statement.BMS will consider for employment qualified
applicants with arrest and conviction records, pursuant to
applicable laws in your area.Any data processed in connection with
role applications will be treated in accordance with applicable
data privacy policies and regulations.
Keywords: Bristol Myers Squibb, Cambridge , Senior Principal Scientist, Computational and Systems Biology, Other , Cambridge, Massachusetts
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