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Sr. Research Associate, Cancer Vaccine Research

Company: Moderna Therapeutics
Location: Cambridge
Posted on: March 17, 2023

Job Description:

Sr. Research Associate, Cancer Vaccine Research page is loaded Sr. Research Associate, Cancer Vaccine Research Apply locations Cambridge, Massachusetts Research time type Full time posted on Posted 4 Days Ago job requisition id R11993 The Role:Moderna Oncology is seeking a talented and motivated Senior Research Associate with experience in immuno-oncology research to support advancement of current and new cancer vaccine programs. The successful candidate will support preclinical research efforts to drive the design of next generation cancer vaccines as well as support clinical stage programs. Research areas of interest include immunology, vaccinology, and dendritic and T cell biology. This is a research position that requires critical thinking, flexibility, multitasking, technical expertise and the ability to learn new techniques . Applicants should be highly collaborative team players, excellent communicators and have a demonstrable track record of research accomplishments. Here's What You'll Do:

  • Develop, optimize and validate cell-based assays to evaluate various mRNA therapeutics
  • Collaborate with internal teams on initial testing of mRNA vaccines and various combinations
  • Collect, archive, organize and analyze samples, including those from in vivo studies
  • Analyze human and murine immune cells and responses, including co-culture assays of dendritic and T cells, via flow cytometry, ELISpot, and ELISA; assist new assay development and technological advancements to query vaccine function and effectiveness
  • Additional experience with molecular biology techniques such as mammalian cell transfection and differentiation are strongly preferred
  • Execute and troubleshoot standard protocols, adapt new protocols into practice with little assistance, and query literature to incorporate additional assays as needed
  • Independently plan experiments
  • Analyze, interpret and present data
  • Faithfully document scientific work
  • Contribute to reports, regulatory submissions and presentations Here's What You'll Bring to the Table:
    • A minimum of a BS degree (MS preferred) and 2-5 years of experience with ex vivo immunological assays such as ELISpot, flow cytometry, as well as culturing immune cells in vitro
    • Background in immunology, cell biology, vaccinology and/or oncology strongly desired
    • Expertise in cell-based assays (e.g. co-culture functional assays, multicolor flow cytometry, live cell imaging, ELISA, cell sorting, etc.)
    • Nucleic acid quantification expertise:
      • Isolation of nucleic acids from cultured cells and harvested tissue
      • Quantification via qPCR, other formats such as bDNA-based approaches
      • Protein quantification expertise:
        • Isolation of protein lysates from cultured cells and harvested tissue
        • Protein quantification via Western, ELISA, MSD, Luminex-based assays
        • Tissue/cell culture expertise:
          • Cell passaging, archiving, transfection and cell-based functional assays
          • Primary cell isolation and culture, particularly with hematopoietic cells
          • Capability to anticipate and recognize potential issues within experimental designs and effectively communicate alternatives
          • Ability to manage multiple projects, prioritize work and meet tight deadlines
          • C andidate will embrace our core values. You will be curious in exploring new paths for drug discovery, bold in proposing creative experimental designs and ideas. Will work collaboratively with multifunctional teams and will be relentless in pursuing successful outcomes that will expand the impact of our cancer vaccines on patients.Moderna is pleased to provide you and your family with a comprehensive and innovative suite of benefits, including:
            • Highly competitive and inclusive medical, dental and vision coverage options
            • Flexible Spending Accounts for medical expenses and dependent care expenses
            • Lifestyle Spending Account funds to help you engage in personal enrichment and self-care activities
            • Family care benefits, including subsidized back-up care options and on-demand tutoring
            • Free premium access to fitness, nutrition, and mindfulness classes -
            • Exclusive preferred pricing on Peloton fitness equipment
            • Adoption and family-planning benefits
            • Dedicated care coordination support for our LGBTQ+ community
            • Generous paid time off, including:
              --- Vacation, sick time and holidays
              --- Volunteer time to participate within your community
              --- D iscretionary year-end shutdown
              --- Paid sabbatical after 5 years; every 3 years thereafter
            • Generous Paid Leave offerings, including 18 weeks of 100% paid parental leave for all new parents
            • 401k match and Financial Planning tools
            • Moderna-paid Life, LTD and STD insurance coverages, as well as voluntary benefit options
            • Complimentary concierge service including home services research, travel booking, and entertainment requests
            • Free parking or subsidized commuter passes
            • Location-specific perks and extras! Candidates should be aware that Moderna currently maintains a policy requiring all US-based employees to be fully vaccinated against COVID-19 and receive a booster shot once eligible . Newly hired employees must be vaccinated and boosted prior to their employment start date. Moderna is an equal opportunity employer and will provide a reasonable accommodation to those unable to be vaccinated or receive a booster where it is not an undue hardship to the company to do so as provided under federal, state, and local law. About ModernaIn over 10 years since its inception, Moderna has transformed from a research-stage company advancing programs in the field of messenger RNA (mRNA), to an enterprise with a diverse clinical portfolio of vaccines and therapeutics across seven modalities, a broad intellectual property portfolio in areas including mRNA and lipid nanoparticle formulation, and an integrated manufacturing plant that allows for rapid clinical and commercial production at scale. Moderna maintains alliances with a broad range of domestic and overseas government and commercial collaborators, which has allowed for the pursuit of both groundbreaking science and rapid scaling of manufacturing. Most recently, Moderna's capabilities have come together to allow the authorized use and approval of one of the earliest and most effective vaccines against the COVID-19 pandemic.Moderna's mRNA platform builds on continuous advances in basic and applied mRNA science, delivery technology and manufacturing, and has allowed the development of therapeutics and vaccines for infectious diseases, immuno-oncology, rare diseases, cardiovascular diseases and autoimmune diseases. Moderna has been named a top biopharmaceutical employer by Science for the past seven years. To learn more, visit .Moderna is a smoke-free, alcohol-free and drug-free work environment.Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Moderna will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.#LI-MBB1- Similar Jobs (4) Sr. Research Associate, Virology, Infectious Disease locations 2 Locations time type Full time posted on Posted 12 Days Ago Senior Research Associate, Autoimmunity & Inflammatory Diseases locations 2 Locations time type Full time posted on Posted 12 Days Ago About Us Our Mission and VisionAt Moderna we are pioneering the development of a new class of drugs made of messenger RNA (mRNA). This novel drug platform builds on the discovery that modified mRNA can direct the body's cellular machinery to produce nearly any protein of interest, from native proteins to antibodies and other entirely novel protein constructs that can have therapeutic activity inside and outside of cells.We have a clear mission to propel the field of mRNA science forward and deliver new medicines to patients and a unique vision for how to achieve this mission.Our Mission: To deliver on the promise of transformative messenger RNA (mRNA) science to bring new medicines to patients.Our Vision: To unlock the potential of mRNA by establishing an ecosystem of teams and partners that will work together to develop the broadest possible array of drugs, across diverse therapeutic areas and routes of administration, for serious diseases that are not treatable today.Third Party Staffing AgenciesM oderna does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Moderna from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Moderna and do not obligate Moderna to pay fees if we hire from those resumes. Reasonable Accommodation NoticeModerna will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.Applicants with disabilities may be entitled to reasonable accommodation under the terms of the Americans with Disabilities Act and certain state or local laws. Please inform the company's personnel representative by calling 617-460-9346 or emailing if you need assistance completing any forms or to otherwise participate in the application process.Examples of reasonable accommodation include making a change to the application process or work procedures, providing documents in an alternate format, using a sign language interpreter, or using specialized equipment.Return Home

Keywords: Moderna Therapeutics, Cambridge , Sr. Research Associate, Cancer Vaccine Research, Other , Cambridge, Massachusetts

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