Principal Scientist, Computational Biology

Company: Bristol Myers Squibb
Location: Cambridge
Posted on: March 15, 2023

Job Description:

Working with UsChallenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: We are looking for a motivated, collaborative computational scientist to join our group in Cambridge, MA. Our science is focused on the development and application of novel screening platforms in disease-relevant model systems to understand disease mechanisms and identify therapeutic opportunities. The successful applicant will design and execute novel analytical approaches in close collaboration with screening and genomics scientists with the aim of generating insights that will initiate drug discovery programs.You will establish methods for the analysis and interpretation of data from emerging profiling techniques, such as phenotypic and functional screens in complex patient-derived disease models. Together with computational and experimental colleagues you will investigate disease states, therapeutic mechanisms, and link patient biology to relevant in-vitro models. Your ability to deeply understand experimental context, develop and apply appropriate statistical methodology, and communicate results to an interdisciplinary team is essential. -This position combines tackling challenging scientific problems with working towards the benefit of patients with unmet medical need. You will be encouraged to contribute creative solutions and to identify new opportunities to accelerate drug discovery through computational innovation.Key Responsibilities

• Develop robust statistical methodology for primary analysis of functional or phenotypic screening experiments
• Closely collaborate with screening scientists to establish best practices for design and execution of novel functional genomics technologies in patient-derived samples or disease-relevant model systems
• Define computational strategies to map patient biology to in-vitro models
• Implement and apply analytical approaches to leverage screening data to validate hypotheses about disease biology and therapeutic mechanismsBasic Qualifications
  • Bachelor's Degree in a relevant area, such as computational biology, computer science, biostatistics or similar and 8+ years of academic / industry experience
  • OR Master's Degree in a relevant area, such as computational biology, computer science, biostatistics or similar and 6+ years of academic / industry experience
  • OR PhD in a relevant area, such as computational biology, computer science, biostatistics or similar and 4+ years of academic / industry experiencePreferred Qualifications
    • Ph.D. in a relevant area, such as computational biology, computer science, biostatistics or similar
    • 3+ years of industry or post-doctoral experience applying quantitative approaches to solve biological or real-world problems
    • Strong statistical programming and data manipulation skills, using contemporary open-source bioinformatics tools (e.g., R/Bioconductor and Python) and databases using readable and reproducible code. Experience with high-performance and cloud computing preferred
    • Experience in analysis of high-throughput molecular data. Experience developing methods to analyze novel functional genomics or sequencing methods would be a strong plus
    • Hands-on experience with state-of-the-art machine learning and/or image analysis methods highly valuable
    • Good understanding of the applicability, advantages and limitations of statistical tests and algorithms.
    • Ability to work independently and to collaborate effectively
    • Excellent communication, data presentation, and visualization skills
    • Fluent in written and oral English#QLR If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.Uniquely Interesting Work, Life-changing CareersWith a single vision as inspiring as "Transforming patients' lives through science--- ", every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.On-site ProtocolPhysical presence at the BMS worksite or physical presence in the field is a necessary job function of this role, which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and it enhances the Company culture.COVID-19 InformationTo protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. -Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. -This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.BMS is dedicated to ensuring that people with disabilities can perform complex functions through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application, or in any part of the recruitment process, direct your inquiries to . Visit to access our complete Equal Employment Opportunity statement.BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

Keywords: Bristol Myers Squibb, Cambridge , Principal Scientist, Computational Biology, Other , Cambridge, Massachusetts