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Principal Scientist, NMR

Company: Bristol-Myers Squibb
Location: Cambridge
Posted on: January 26, 2023

Job Description:

Working with UsChallenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science. In oncology, hematology, immunology, and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference. - - - - -Position SummaryWe are seeking a talented and motivated Ph.D. Nuclear Magnetic Resonance spectroscopist to join the Synthesis and Enabling Technologies team within the Small Molecule Drug Discovery department at Bristol Myers Squibb. The candidate will work in a highly innovative environment tackling new challenges and paving the way for emerging areas of research alongside a cross-functional team of scientists in Cambridge, Massachusetts. The candidate will have exciting opportunities to engage in NMR research that contribute to the discovery of new drug candidates to help patients overcome serious diseases. The candidate will contribute to structure elucidation, structure-function relationship assessments, batch characterization and other relevant biophysical assessments using NMR spectroscopy. This position will focus on all aspects of NMR spectroscopy including the day-to-day operation of our state-of-the-art NMR facility consisting of 400-600 MHz spectrometers, some equipped with cryoprobe technology.Job Responsibilities

  • Apply NMR spectroscopy to gain atomic level information of molecules from diverse drug modalities for the successful identification and advancement of lead candidates for drug discovery programs.
  • Partner with numerous groups across our research and early development department and effectively work with matrix teams to meet project milestones. Manage multiple concurrent projects and adjust to changing priorities.
  • Design NMR approaches and methods which produce timely, high quality, data driven contributions to advance our research initiatives.
  • Maintain NMR state-of-the-art facilities at BMS in Cambridge, MA by leveraging our cryogenic NMR technology platforms and implementing the latest NMR methodologies, pulse sequences, and vendor product offerings.
  • Oversee the day-to-day operations including routine NMR spectrometer maintenance, instrument calibration and optimization, software updates, and working with vendors for installations.
  • Train and support medicinal chemists in the use of the open access NMR instrumentation; provide expert guidance on available experiments and methods most appropriate for their research samples and projects.Basic Qualifications:
    • Bachelor's Degree with 8+ years of academic / industry experience OR
    • Master's Degree with 6+ years of academic / industry experience OR
    • PhD with 4+ years of academic / industry experiencePreferred Qualifications:
      • Ph.D. degree in Analytical Chemistry, Organic Chemistry, or related discipline with at least 4+ years of hands-on experience in high-resolution, solution state NMR spectroscopy
      • Experience with NMR approaches for the structural characterization of small molecules and other drug modalities is expected; biomolecular and/or solid-state NMR is a plus.
      • Demonstrated record of productivity in NMR spectroscopy as evidenced by publications, and graduate research or industrial positions.
      • Experience with NMR spectrometers required; working knowledge of Bruker NMR spectrometers is desired. Proven aptitude for troubleshooting NMR hardware and software issues. Familiarity with NMR processing software such as ACD and MNOVA is a plus.
      • Thoroughly familiar with and be able to independently accomplish acquisition and interpretation of multinuclear and multidimensional NMR experiments.
      • Familiarity with Linux systems and programming skills are a plus.
      • Critical scientific thinking, and a demonstrated ability to carry out independent research are required. A strong interest and motivation to learn new technologies and concepts is expected.
      • Excellent written and oral communication skills, and ability to promote a collaborative and inclusive work environment.If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.Uniquely Interesting Work, Life-changing CareersWith a single vision as inspiring as "Transforming patients' lives through science--- ", every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.On-site ProtocolPhysical presence at the BMS worksite or physical presence in the field is a necessary job function of this role, which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and it enhances the Company culture.COVID-19 InformationTo protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. -Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. -This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.BMS is dedicated to ensuring that people with disabilities can perform complex functions through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application, or in any part of the recruitment process, direct your inquiries to . Visit to access our complete Equal Employment Opportunity statement.BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

Keywords: Bristol-Myers Squibb, Cambridge , Principal Scientist, NMR, Other , Cambridge, Massachusetts

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