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Senior Research Scientist I - Biochemistry/Biophysics

Company: The Broad Institute
Location: Cambridge
Posted on: January 26, 2023

Job Description:

Job Description

Embedded within the Broad Institute of MIT & Harvard, the Center for the Development of Therapeutics (CDoT) is a highly collaborative organization of professional scientists. Our mission is to translate the deep biological insights originating from the Broad community into impactful drug discovery projects. We integrate faculty from MIT, Harvard, and the Harvard teaching hospitals with industry partners to execute drug discovery projects. We combine our expertise in drug discovery with the knowledge and unique capabilities of the Broad Institute to address a wide range of disease areas including oncology, cardiovascular and metabolic diseases, psychiatric disorders, infectious disease, and rare diseases.

Our goal is to embrace Broad's culture of creativity and open sharing to de-risk therapeutic hypotheses, validate new targets, and advance new therapies that will improve human health. The Broad Institute is dedicated to increasing the diversity across the institute. Candidates who have experience working with a diverse range of staff and who can contribute to the climate of belonging and inclusivity are encouraged to identify their skills in these areas when applying.

The primary role for this position is to enable therapeutic discovery by developing biochemical and/or biophysical assays to guide early-stage drug discovery programs. The successful candidate will have a demonstrated track record of developing biochemical and/or biophysical assays to guide small molecule hit identification, hit validation and routine screening. The role requires the interpretation of experimental results and clear communication of those results to cross-functional project teams. The role will involve transferring and establishing routine assays at external CRO's and management of those activities.


* Biochemical and/or biophysical assay design, development and validation

* Design and execution of screening campaigns. Data analysis, hit calling and hit confirmation.

* Implementation of automated solutions for sample preparation and data analysis

* Interpretation of experimental results and communication of those results to cross-functional project team members in a clear and concise manner

* Technical leadership and participation in project teams

* Documentation of work in a digital notebook (ELN) and routine uploading of experimental results to a central database

* Transfer of assays to external CRO's and scientific oversight of work at CRO's


* Ph.D. in Biochemistry, Biophysics, or a related life science field with at least 2 years (Research Scientist II) or 5 years (Senior Research Scientist I) of relevant experience

* Significant experience testing small molecules in biochemical or biophysical assays is required

* Technical expertise in multiple biophysical (SPR, ITC, BLI, MST) and/or biochemical (enzyme assays, FRET, FP) is required

* Experience in Mass Spectrometry is highly desirable

* A proven record of successful participation in cross-functional project teams and communication with external vendors and partners to achieve high-quality results

The successful candidate will be a results-focused, team-oriented, creative, bench scientist, able to excel in a fast-track environment. They must be self-motivated, detail-oriented and exhibit strong problem-solving skills. In addition, the successful candidate should be a clear and effective communicator, demonstrating strong relational skills to enable participation in project teams, peers, and management in identifying and achieving research goals.

Broad culture:

We pride ourselves on being creative and forward-thinking not only in the way we approach our science but also in the way we support our people.

Check out a sampling of our benefits:

* 3 weeks vacation within the first year, 13 paid holidays plus an annual winter closing from Christmas to New Year's

* Commuter passes subsidized at 50%

* Tuition reimbursement up to $5,250 per calendar year

* Free FitBit

* Fooda, on-site lunch available for purchase from local vendors every day

* LeanBox, vending machine of fresh, healthy snacks available at subsidized prices

* Free on-site yoga, meditation and boot camp

* Discounts on entertainment, goods, and services through Working Advantage

* Regular seminars and discussion groups hosted by our BroadLife office to help you deal with a diverse array of work-life issues and make it easier to integrate work, personal and family commitments


* Normal laboratory conditions

* Normal office conditions

All Broad employees, regardless of work location, must be fully vaccinated for COVID-19 by Tuesday, October 12, 2021. Requests for exemption for medical or sincerely held religious beliefs will be considered.

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.

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Keywords: The Broad Institute, Cambridge , Senior Research Scientist I - Biochemistry/Biophysics, Other , Cambridge, Massachusetts

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