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DSP Expert Scientist Polysaccharides - Carrier Unit

Company: GlaxoSmithKline
Location: Cambridge
Posted on: January 25, 2023

Job Description:

Site Name: Cambridge Binney StreetPosted Date: Dec 20 2022Be the human face of cutting-edge healthcareWe're combining the power of genetic and genomic insights into what causes disease, with the speed and scale of artificial intelligence and machine learning (AI/ML) to make better predictions about who a treatment might work for, and why. We believe this powerful combination of data and technology holds the key to fundamentally transforming medical discovery for the better, improving R&D success rates and shaping how even the most challenging diseases, like neurological conditions and cancer, can be both prevented and treated.Within the Carrier Unit group, you will integrate with a multidisciplinary team in charge of purification and characterization of recombinant proteins and polysaccharides. You will be in close contact with experts in upstream, downstream and various analytical technologies.Your mission will be focused on deep process and product understanding of polysaccharide purification, modification and complexation in different research and development contexts (early development, processability, process development, process understanding, troubleshooting, Life cycle---). The successful candidate will report to the manager of Carrier Unit, which is part of the Microbial Drug Substance organization in Technical R&D (TRD).Your Responsibilities:As Expert Scientist Polysaccharides, you will: -Design, manage and execute studies relevant to MAPS process development and product/process understanding to advance novel vaccine programs from preclinical through clinical stages. -Support and manage novel programs including in-house development, tech transfer to CMOs and providing oversight to GMP manufacturing. -Develop new processes or improve existing processes using scientific expertise, literature review or by seeking inputs from Subject Matter Experts. -Provide scientific/technical expertise to develop new Biochemical/ Biophysical methods to support vaccine process development. -Analyze data from process development studies and author reports for internal and external submission, including regulatory agencies such as the FDA. -Provide mentorship and guidance to more junior members of the team. -Benchmark specific technologies in own functional area to bring technology to state-of-the-art. -Ensure proactive scientific/technology watch within your own competency domain -Provide scientific and technical leadership in your own area of expertise and spread knowledge across the whole organization. -Be responsible for technical follow-up of external collaborations as needed.Why you?Basic Qualifications: -MS in related fields such as Organic Chemistry or Chemical Engineering with 6-10 years of relevant experience. A PhD in a relevant field with 1-5 years of experience may also be considered. -Extensive knowledge of polysaccharide chemistry and characterization including NMR -Hands-on experience in polysaccharide purification -Experience in technology transfer and scale-up of polysaccharide processes -Independent, detail-oriented and organized -Demonstrated leadership experience and ability to perform in a dynamic environment with a strong work ethic. -As the group is a multidisciplinary organization, the willingness to develop beyond the initial expertise is a prerequisite to apply to this position. -Excellent writing, communication and influencing skills. -Interest for the laboratory work and lab management -Team spirit -Autonomy, scientific rigor, analytical mindset -Scientific curiosityPreferred Qualifications: -PhD in related fields such as Chemical Engineering or Organic Chemistry. -Experience and training with DOE (Design of Experiments) and knowledge of QbD (Quality by Design) -Understanding of operations and GMP manufacturing -Good organization skills (day-to-day operations and lab management). -Ability to embrace/drive changes positively. -Imprinted with a desire for excellence. -Optimistic and open-minded. -Networking skillsWhy GSK?We want GSK to be a workplace where everyone can feel a sense of belonging and thrive. We're committed to being more proactive at all levels so that our workforce reflects the communities we work and hire in, and our GSK leadership reflects our GSK workforce. #GSKBinneyStreet#LI-GSKGSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive. Getting ahead means preventing disease as well as treating it, and we aim to impact the health of 2.5 billion people around the world in the next 10 years.Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a workplace where everyone can feel a sense of belonging and thrive as set out in our Equal and Inclusive Treatment of Employees policy. We're committed to being more proactive at all levels so that our workforce reflects the communities we work and hire in, and our GSK leadership reflects our GSK workforce.If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.At GSK, the health and safety of our employees are of paramount importance. As a science-led healthcare company on a mission to get ahead of disease together, we believe that supporting vaccination against COVID-19 is the single best thing we can do in the US to ensure the health and safety of our employees, complementary workers, workplaces, customers, consumers, communities, and the patients we serve.GSK has made the decision to require all US employees to be fully vaccinated against COVID-19, where allowed by state or local law and where vaccine supply is readily available. The only exceptions to this requirement are employees who are approved for an accommodation for religious, medical or disability-related reasons.Important notice to Employment businesses/ AgenciesGSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting site.

Keywords: GlaxoSmithKline, Cambridge , DSP Expert Scientist Polysaccharides - Carrier Unit, Other , Cambridge, Massachusetts

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