Senior Principal Scientist Molecular Discovery
Company: Pfizer
Location: Cambridge
Posted on: January 22, 2023
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Job Description:
Pfizer's Biotherapeutic Discovery group in Cambridge is seeking
an outstanding, highly motivated scientist with strong background
in molecular biology, protein expression and protein
biology/structure, to join a multidisciplinary team responsible for
supporting the discovery, characterization, and refinement of
therapeutic proteins. This Principal Scientist will collaborate
with therapeutic project leaders across various Disease Areas to
understand the target biology and design custom drug target-related
DNA, RNA, protein and cell-based reagents. -The candidate will have
access to state-of-the-art technologies and will be expected to
continue our tradition of developing world class methods and
technologies that enhance our therapeutic discovery efforts.Job
Responsibilities: ---- Serve as liaison between the Target Protein
Sciences (TPS) group and project teams to advise on best approaches
for design and production of critical reagents for therapeutic
protein discovery and characterization.--- Provide strategic
direction and implement innovative approaches across multiple
modalities.--- Demonstrate an understanding of the underlying
biology and mechanisms of action for a variety of drug targets.---
Direct the creation of diverse expression constructs for production
in a variety of hosts as necessary, and coordinate with TPS
expression and purification groups for optimal production and
characterization.BASIC QUALIFICATIONS ---- Ph.D. in Biological
Science (Molecular Biology, Structural Biology, Protein
Biochemistry, Cell Biology) or a related field, at least 8 years of
post-graduate experience and proven experience in recombinant
protein design, protein engineering and production in biotech or
biopharmaceutical industry is required.--- Strong familiarity with
recombinant protein expression in various prokaryotic and
eukaryotic hosts, and protein purification methods.--- Experience
and knowledge of gene expression and regulation in prokaryotic and
eukaryotic cells.--- Strong track record of scientific
accomplishments demonstrated through publications in highly
regarded journals and/or intellectual property generation.--- An
innovator with a proven track record in molecular design of
recombinant proteins and cell lines, a creative and proactive
approach to problem solving, strong analytical skills and attention
to detail.--- A highly collaborative scientist with broad interests
and a diverse background. An ability to work across disciplines and
understand the specific needs of collaborators.--- Strategic
thinking with an ability to understand program and therapeutic area
needs and translate that understanding into an actionable
approach.--- Outstanding interpersonal, collaborative and oral
communication skills.--- Strong motivation, passion and commitment
to science and engineering of large-molecule therapeutics---
Ability to critically analyze and interpret work published in the
field and apply it appropriately.--- Strong time management skills
and ability to manage multiple projects in parallel.--- Strong
communication skills and ability to present research in a team
setting.--- The individual should be scientifically creative and
driven by a willingness to embrace innovation within drug discovery
and an eagerness to challenge and meet aggressive
timelines.PREFERRED QUALIFICATIONS--- Proven managerial skills and
success in mentoring and managing a group of scientists with
diverse expertise and levels of experience, providing decisive
prioritization and communicating project needs transparently.---
Demonstrate a breadth of diverse leadership experiences and
capabilities including the ability to influence and collaborate
with peers, develop and coach others, oversee and guide the work of
colleagues to achieve meaningful outcomes and create business
impact.--- Knowledge of structural biology methods and requirements
for protein reagentsRelocation support available.Work Location
Assignment: -On Premise
Relocation assistance may be available based on business needs
and/or eligibility.
Pfizer requires all U.S. new hires to be fully vaccinated for
COVID-19 prior to the first date of employment. - As required by
applicable law, Pfizer will consider requests for Reasonable
Accommodations.Sunshine ActPfizer reports payments and other
transfers of value to health care providers as required by federal
and state transparency laws and implementing regulations. - These
laws and regulations require Pfizer to provide government agencies
with information such as a health care provider's name, address and
the type of payments or other value received, generally for public
disclosure. - Subject to further legal review and statutory or
regulatory clarification, which Pfizer intends to pursue,
reimbursement of recruiting expenses for licensed physicians may
constitute a reportable transfer of value under the federal
transparency law commonly known as the Sunshine Act. - Therefore,
if you are a licensed physician who incurs recruiting expenses as a
result of interviewing with Pfizer that we pay or reimburse, your
name, address and the amount of payments made currently will be
reported to the government. - If you have questions regarding this
matter, please do not hesitate to contact your Talent Acquisition
representative.EEO & Employment EligibilityPfizer is committed to
equal opportunity in the terms and conditions of employment for all
employees and job applicants without regard to race, color,
religion, sex, sexual orientation, age, gender identity or gender
expression, national origin, disability or veteran status. - Pfizer
also complies with all applicable national, state and local laws
governing nondiscrimination in employment as well as work
authorization and employment eligibility verification requirements
of the Immigration and Nationality Act and IRCA. - Pfizer is an
E-Verify employer.Research and Development
Keywords: Pfizer, Cambridge , Senior Principal Scientist Molecular Discovery, Other , Cambridge, Massachusetts
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