DSP Scientist, Carrier Unit

Company: GlaxoSmithKline
Location: Cambridge
Posted on: January 20, 2023

Job Description:

Site Name: Cambridge Binney StreetPosted Date: Jan 16 2023We're combining the power of genetic and genomic insights into what causes disease, with the speed and scale of artificial intelligence and machine learning (AI/ML) to make better predictions about who a treatment might work for, and why. We believe this powerful combination of data and technology holds the key to fundamentally transforming medical discovery for the better, improving R&D success rates and shaping how even the most challenging diseases, like neurological conditions and cancer, can be both prevented and treated.Job Purpose:Within the Carrier Unitgroup, you will integrate with a multidisciplinary team in charge of fermentation and purification of recombinant proteins and polysaccharides. You will be in close contact with experts in upstream, downstream and various analytical technologies. Your mission will be focused on the development and execution of downstream processes in different research and development contexts (early development, processability, process development, process understanding, troubleshooting, Life cycle---).You will report to the manager of Carrier Unit, which is part of the Microbial Drug Substance organization in Technical R&D (TRD).Your Responsibilities:AsScientistDownstream Process, you will:

• Develop, optimize, and scale-up downstream protein purification processes.
• Execute large scale purifications using depth filtration, centrifugation, chromatography and tangential flow filtration (TFF).
• Characterize proteins using SDS-PAGE, BCA assay, and other biochemical assays to determine protein purity and quality attributes.
• Write batch records for fermentation and expression protocols.
• Transfer developed processes to GMP facilities / CMOs to support Phase I/II trials.
• Understand project timelines/deliverables, support, and coordinate cross-functional activities to achieve team and company goals.
• Document, summarize and present dataWhy you?Basic Qualifications:
  • BS/MS in related fields such as Chemical Engineering, Bioengineering, Biochemistry, or Biology, with 3-5 years of relevant experience.
  • Knowledge of bioprocess engineering principles including chromatography and filtration.
  • Hands on experience working with AKTA and TFF systems.
  • Experience with protein characterization using SDS-PAGE and other biochemical assays.
  • Independent, detail-oriented and organized.
  • Demonstrated ability to work in a dynamic environment as a team player with a strong work ethic.
  • As the group is a multidisciplinary organization, the willingness to develop beyond the initial expertise is a prerequisite to apply to this position.
  • Good writing, communication and influencing skills.
  • Interest for the laboratory work and lab management
  • Team spirit
  • Scientific curiosityPreferred Qualifications:
    • Experience in technology transfer and scale-up of drug substance processes
    • Experience and training with DOE (Design of Experiments) and knowledge of QbD (Quality by Design)
    • Understanding of operations and GMP manufacturing
    • Experience in upstream processing, analytical methods, and data analysis
    • Good organization skills (day-to-day operations and lab management).
    • Imprinted with a desire for excellence.Why GSK?We want GSK to be a workplace where everyone can feel a sense of belonging and thrive. We're committed to being more proactive at all levels so that our workforce reflects the communities we work and hire in, and our GSK leadership reflects our GSK workforce. #GSKBinneyStreet #GSKAffinivax#LI-GSKGSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive. Getting ahead means preventing disease as well as treating it, and we aim to impact the health of 2.5 billion people around the world in the next 10 years.Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a workplace where everyone can feel a sense of belonging and thrive as set out in our Equal and Inclusive Treatment of Employees policy. We're committed to being more proactive at all levels so that our workforce reflects the communities we work and hire in, and our GSK leadership reflects our GSK workforce.If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.At GSK, the health and safety of our employees are of paramount importance. As a science-led healthcare company on a mission to get ahead of disease together, we believe that supporting vaccination against COVID-19 is the single best thing we can do in the US to ensure the health and safety of our employees, complementary workers, workplaces, customers, consumers, communities, and the patients we serve.GSK has made the decision to require all US employees to be fully vaccinated against COVID-19, where allowed by state or local law and where vaccine supply is readily available. The only exceptions to this requirement are employees who are approved for an accommodation for religious, medical or disability-related reasons.Important notice to Employment businesses/ AgenciesGSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting site.

Keywords: GlaxoSmithKline, Cambridge , DSP Scientist, Carrier Unit, Other , Cambridge, Massachusetts