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Senior Associate Scientist, Neuroscience

Company: Bristol Myers Squibb
Location: Cambridge
Posted on: January 18, 2023

Job Description:

At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science. In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.When you join BMS, you are joining a diverse, high-achieving team united by a common mission. The Neuroscience TRC is committed to development of transformational therapeutics for patients with neurodegenerative and neuromuscular diseases. We have built a network of external partnerships across multiple treatment modalities (small molecules, biologics and RNA targeting) that leverage our leadership in protein homeostasis and inflammation to attach neurological diseases. Internal research focuses on protein homeostasis by direct and ligand directed degradation, neuroinflammation and remyelination.Areas of interest include, but are not limited to, the following approaches:Disease modifying therapies for neurodegenerative, neuro-inflammatory and neuromuscular diseases; CNS targets that modulate protein homeostasis, protein clearance, inflammation and reduce or eliminate toxic protein production; Emerging technologies (RNA, DNA targeting, gene regulation, editing and replacement, vector optimization) that when matched to underlying disease genetics can deliver a precision medicine portfolio with a high probability of success to address unmet medical needs; Targets in orphan/rare neurological and neuromuscular diseases. AI/ML in target identification and neurology drug discovery; Translational tools and technologies such as digital neuroimaging and fluid biomarkers to track neurodegenerative diseases; Novel blood brain-barrier delivery technologies.Here, you'll get the chance to grow and thrive through opportunities that are uncommon in scale and scope. You'll pursue innovative ideas while advancing professionally alongside some of the brightest minds in biopharma.Position Summary:The Senior Associate Scientist will work in a small team dedicated to evaluation of new opportunities for drug discovery in neurodegenerative diseases affecting a large and growing number of patients throughout the world including Alzheimer's, Parkinson's, Huntington's and ALS. The group is focused on developing new cell-based approaches to rapidly model and modulate processes driving neurodegeneration and neuroprotection. Position Responsibilities:In the role as a Senior Associate Scientist within the Neuroscience TRC, the ideal candidate will:

  • Participate in target discovery, target validation, and drug discovery.
  • Use a variety of biological approaches including signal transduction assays, functional assays, and high content imaging to model degenerative processes and analyze the effect of target modulation.
  • Apply techniques to cell culture models including established cell lines, primary neurons and iPSC-derived cultures.
  • Have the opportunity to participate in a variety of projects within our department, with external collaborators as well as lead their own projects. Experience = Basic Qualifications:
    • Bachelor's Degree
      • 4+ years of academic and / or industry experienceOr
        • Master's Degree
          • 2+ years of academic and / or industry experiencePreferred Qualifications:
            • Master's degree in an appropriate scientific discipline. Candidates with a Bachelors' degree and significant post-graduate research experience are also encouraged to apply. Prior work experience in industrial settings is highly preferred.
            • Significant drug discovery experience emphasizing neuroscience and disease modeling, assay development and high throughput cell biology.
            • Demonstrated expertise in molecular and cell biology, signal transduction assays, microscopy and high content imaging.
            • Extensive expertise in mammalian cell culture is required: Construct delivery, generation of stable cell lines, clonal selection, etc. Utilization of iPSC systems particularly in neuroscience is highly preferred.
            • Ability to conduct experimental work independently, with accurate, detailed record-keeping.
            • Ability to summarize and interpret scientific data in a clear, concise and accurate manner.
            • Great oral and written communications with peers and supervisors and a good team player. #LI-OnsiteBMSNEUROAround the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

Keywords: Bristol Myers Squibb, Cambridge , Senior Associate Scientist, Neuroscience, Other , Cambridge, Massachusetts

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