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Scientist I, Rare Disease

Company: Takeda Pharmaceutical
Location: Cambridge
Posted on: November 24, 2022

Job Description:

By clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda's Privacy Notice and Terms of Use . I further attest that all information I submit in my employment application is true to the best of my knowledge.

Job Description

About the role:

  • At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on four therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide.
  • We are looking for a highly motivated biologist/biochemist to characterize in vitro model systems and in vivo studies in support of ongoing programs in the Rare Metabolic therapeutic area in the Department of Rare Diseases Drug Discovery Unit.
  • Join Takeda as a Scientist I, Rare Disease, based in Cambridge, MA. How you will contribute:

    • Design, validate and develop cell-based assays to characterize pharmacologic responses to a range of therapeutic modalities, including, small molecules or biologics such as recombinant proteins and viral-mediated delivery
    • Conduct test article validation, pharmacology, and mechanistic studies in a variety of in vitro , ex vivo cell culture models and in vivo study
    • Utilize test articles to dissect pathways of interest and evaluate targets with a focus on metabolic pathways related to lysosomal storage diseases
    • Collaborate closely with stakeholders from other departments, prepare scientific presentations and regularly participate in multidisciplinary team meetings
    • Interact with external vendors and academic collaborators on a routine basis
    • Generate scientific reports, electronic notebook and, when appropriate, manuscripts for publication DIMENSIONS AND ASPECTS
      • Outstanding technical expertise in mammalian cell culture, including primary cell culture
      • Significant experience in diverse in vitro techniques including but not limited to cellular immunofluorescence, MSD-ELISA, Western blot, enzymatic activity assays, reporter gene assays
      • Ability to develop, perform, and analyze plate-based primary and secondary pharmacology assays
      • Understand the principles of lysosomal storage diseases and the use of test articles as a proof-of-concept in vitro and in vivo
      • Generate scientific reports, electronic notebook and, when appropriate, manuscripts for publication Minimum Requirements/Qualifications:
        • PhD degree in a scientific discipline (or equivalent), or MS with 6+ years relevant experience, or BS with 8+ years relevant experience
        • Strong influencing, communication and presentation skills
        • Demonstrated ability to work across functions and cultures
        • Excellent communicator, able to persuasively convey both ideas and data, verbally and in writing
        • Embraces and demonstrates a diversity and inclusion mindset and role models these behaviors for the organization
        • Strong collaboration skills and ability to lead in cross-functional environment What Takeda can offer you:
          • Comprehensive Healthcare: Medical, Dental, and Vision
          • Financial Planning & Stability: 401(k) with company match and Annual Retirement Contribution Plan
          • Health & Wellness programs including onsite flu shots and health screenings
          • Generous time off for vacation and the option to purchase additional vacation days
          • Community Outreach Programs and company match of charitable contributions
          • Family Planning Support
          • Flexible Work Paths
          • Tuition reimbursement More about us:

            At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.

            Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

            In accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply.

            EEO Statement

            Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.


            Boston, MA

            Worker Type

            Worker Sub-Type

            Time Type

            Full time

Keywords: Takeda Pharmaceutical, Cambridge , Scientist I, Rare Disease, Other , Cambridge, Massachusetts

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