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Neuroinflammation Senior Scientist

Company: Bristol Myers Squibb
Location: Cambridge
Posted on: November 24, 2022

Job Description:

At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science. -In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

When you join BMS, you are joining a diverse, high-achieving team united by a common mission.

The Neuroscience TRC is committed to development of transformational therapeutics for patients with neurodegenerative and neuromuscular diseases. We have built a network of external partnerships across multiple treatment modalities (small molecules, biologics and RNA targeting) that leverage our leadership in protein homeostasis and inflammation to attach neurological diseases. Internal research focuses on protein homeostasis by direct and ligand directed degradation, neuroinflammation and remyelination.

Areas of interest include, but are not limited to, the following approaches:
Disease modifying therapies for neurodegenerative, neuro-inflammatory and neuromuscular diseases; CNS targets that modulate protein homeostasis, protein clearance, inflammation and reduce or eliminate toxic protein production; Emerging technologies (RNA, DNA targeting, gene regulation, editing and replacement, vector optimization) that when matched to underlying disease genetics can deliver a precision medicine portfolio with a high probability of success to address unmet medical needs; Targets in orphan/rare neurological and neuromuscular diseases. AI/ML in target identification and neurology drug discovery; Translational tools and technologies such as digital neuroimaging and fluid biomarkers to track neurodegenerative diseases; Novel blood brain-barrier delivery technologies.

Here, you'll get the chance to grow and thrive through opportunities that are uncommon in scale and scope. You'll pursue innovative ideas while advancing professionally alongside some of the brightest minds in biopharma.

Position Summary:
We seek a talented scientist to combine expert knowledge in neuroscience and neuroinflammation to enable the discovery and development of new therapeutics in the Neuroscience Thematic Research Center (NS TRC). - In this role, the successful candidate will develop new approaches to target and drug discovery in neurodegeneration, develop approaches to utilize human inducible pluripotent stem cell derived neurons and glial cells for drug discovery and help progress projects from target validation to therapeutic discovery and clinical development.

The successful candidate will be an important member of NS Discovery Biology group, located in MA. The NS TRC is a highly collaborative department, working across our locations with many colleagues throughout the Research & Early Development (R/ED) organization and with an array of external academic and biotechnology groups. - The position offers an exciting opportunity to make a difference in lives of patients, gain industry experience, and interact with the broader scientific community. - The successful candidate will also be encouraged to publish their work and to present at external meetings and conferences.

Position Responsibilities:
In the role as a Senior Scientist within the Neuroscience TRC Discovery Biology team, the ideal candidate:
Develops and uses cell-based models to validate novel targets in neurodegeneration

Utilizes iPSC derived neurons and microglial cells to model neuroinflammatory processes, validate novel therapeutic strategies and develop novel therapeutics

Participates and helps lead external collaborations with academic and biotechnology groups to help progress our target and drug discovery efforts.

Works with our NS team to identify new opportunities for target validation and drug discovery evolving in the field.

Works within our drug discovery programs to characterize, optimize, and progress new molecular entities to the clinic.

Works with our technology groups to advance our ability to create patient relevant models of neurodegeneration, neuronal glial interaction and neuroinflammation.

Experience =

Basic Qualifications:
Bachelor's Degree
7+ years of academic and / or industry experience

Master's Degree
5+ years of academic and / or industry experience

Ph.D. or equivalent advanced degree in the Life Sciences
2+ of academic and / or industry experience

Preferred Qualifications:
A Ph.D. in a relevant biological field, such as neuroscience, molecular biology or genetics and at least 3 years post graduate experience. Candidates with a Masters and at least 5 years of experience and relevant skills will also be considered.

Demonstrated experience and success in modelling relevant processes in neurobiology or neuroinflammation and expertise in stem cell biology, high throughput or imaging-based approaches to biology.

Excellent communication skills, enthusiasm for lab work in a team environment and vigorous open scientific exchange are essential.


Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.

To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. - Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. - This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to . Visit to access our complete Equal Employment Opportunity statement.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

Keywords: Bristol Myers Squibb, Cambridge , Neuroinflammation Senior Scientist, Other , Cambridge, Massachusetts

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