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Scientist 1/2 - Protein Biochemistry

Company: Affinivax Inc.
Location: Cambridge
Posted on: November 23, 2022

Job Description:

About Affinivax
Affinivax is a Cambridge-based clinical-stage biotechnology company with a novel, next-generation approach to the development of vaccines and immunotherapies targeting infectious and other immune-mediated diseases. This novel and highly efficient vaccine technology - called Multiple Antigen Presenting System (MAPS) - enables the high-affinity binding of protective polysaccharides as well as proteins in a single vaccine, uniquely inducing a broad and protective B-cell and T-cell immune response.
Our vision is to take a major step forward in vaccine innovation to prevent and combat a wide range of infectious and other immune-mediated diseases, protecting infants and adults in our communities and making a meaningful impact on global public health. Affinivax is focused on developing vaccines for the most challenging bacterial infections, with a goal of improving upon existing vaccines and providing solutions for where there are no vaccines or prevention strategies available today.
The role---
GSK-Affinivax is currently seeking a highly motivated scientist with expertise in protein expression, purification, and analytical characterization techniques to join our protein science team. The protein science team at GSK-Affinivax is responsible for generating high quality protein antigens from different bacterial and viral pathogens to support our vaccine development programs. The scientist will work closely with the members from immunology and molecular biology groups in a collaborative environment providing ample opportunity to learn and grow within the cross functional team.
You will have the opportunity to---

  • Design and propose recombinant protein expression constructs based on available structural or homology modeling data.
  • Develop and optimize purification protocols for different recombinant proteins (with and without affinity tags) using various chromatographic methods (Affinity, IEX, HIC).
  • Characterize purity and homogeneity of the purified proteins using various analytical and biophysical tools e.g. analytical SEC, SEC-MALS, DLS, DSF etc.
  • Independently troubleshoot challenges and come up with novel solutions.
  • Author, review, and approve SOPs, study protocols, reports, and other scientific and quality documents.
  • Present scientific data to colleagues in group meetings and prepare and present internal and external presentations.
  • Present progress updates to senior management.
    Who you are and what you bring to the team---
    • Ph.D. (Biochemistry, Molecular Biology, Structural biology or related discipline) with 1+ years of post-graduate experience, MS or BS degree in Biochemistry, Chemical Engineering or process science with 5+ years of work experience in optimizing protein purification protocol and scale up.
    • Extensive hands-on working experience with recombinant protein expression and purification is needed.
    • Prior experience of working in a pharmaceutical industry and purification process development is preferred.
    • Experience in other bio-physical binding assay development methods, such as SPR, MST, FP is a plus.
    • Strong ability to multi-task and willingness to work effectively in a highly collaborative and diverse environment as a team player with a strong work ethic.
    • Able to maintain written records in the form of laboratory notebooks.
    • Strong written and oral communication skills.
      What We Offer
      • Competitive compensation
      • Medical and Dental plans (BCBS), employer-paid at 85%
      • Vision Insurance, employer-paid at 100%
      • Life Insurance, Short- and Long-Term Disability
      • Flexible Spending Accounts/Health Savings Accounts
      • Wellness Benefits
      • 401(k) Plan with a 4% match
      • Tuition Reimbursement
      • Generous PTO package
      • 11 paid holidays, plus Holiday Shutdown
      • Pet Insurance
      • Subsidized Parking
      • Commuter Reimbursement Program
      • Brand new facility in Kendall Square
        Please Note
        In accordance with Affinivax's duty to provide and maintain a safe workplace that is free of known hazards, we have adopted a COVID-19 vaccine policy to protect the health of our employees and their families, our visitors, and the community at large from COVID-19. This policy requires all employees, contractors, and temporary workers, to (1) obtain an approved vaccination and provide proof of vaccination or (2) request an accommodation for a medical or religious exemption. Our policy is based on guidance from the Centers for Disease Control (CDC) and Prevention.
        Affinivax is committed to providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, national origin, age, disability, genetic information, status as a veteran or as a member of the military or status in any group protected by applicable federal or state laws.
        Agencies
        All resumes submitted by search firms/employment agencies to any employee at Affinivax via email, the internet, or in any form and/or method will be deemed the sole property of Affinivax, unless such search firms/employment agencies were engaged by Affinivax for this position and a valid agreement with Affinivax is in place. In the event a candidate who was submitted outside of the Affinivax agency engagement process is hired, no fee or payment of any kind will be paid.

Keywords: Affinivax Inc., Cambridge , Scientist 1/2 - Protein Biochemistry, Other , Cambridge, Massachusetts

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