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Scientist, Analytical Development

Company: Intellia Therapeutics
Location: Cambridge
Posted on: November 23, 2022

Job Description:

Why Join Intellia?Our mission is to develop curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases.Beyond our science, we live our four core values: One, Explore, Disrupt, Deliver and feel strongly that you can achieve more at Intellia. We have a single-minded determination to excel and succeed together. We believe in the power of curiosity and pushing boundaries. We welcome challenging thoughts and imagination to develop innovative solutions. And we know that patients are counting on us to make the promise a reality, so we must maintain high standards and get it done.We wantall ofour people to go beyond what is possible. We aren't constrained by typical end rails, and we aren't out to just "treat" people. We're all in this for something more. We're driven to cure and motivated for change. Just imagine the possibilities of what we can do together.How You Will Achieve More with Intellia: We are excited to welcome this new member to our growing team and company. This is both a strategic and hands-on role. If you are a strong and independent problem-solver, agile, detail-oriented with a strong technical background in primary T cell culture, flow cytometry, analytic development, and potency assays, and enjoy working in cross-functional teams, this is the role for you! As a Scientist, you will work on various activities including:

  • Develop, optimize and in-house qualification of cell-based potency assays and characterization assays with established assay acceptance criteria for gene & cell therapy product characterization, lot release and stability testing
  • Establish parameters required to initiate tech transfer
  • Act as SME in tech transfer of analytical methods, protocols/procedures and know-how from internal labs to external labs
  • Oversee assay development and routine testing at CRO
  • Lab operation: Routine and non-routine analytical testing, coordination with internal/external PD or cGMP manufacturing on sample testing, maintaining laboratory equipment, maintaining laboratory sample inventory for potency assay, compiling and present data to support process development and developmental stability studies
  • Evaluate novel assay technologies and methodologies that could improve existing analytical methods for potency assaysThis is a unique role that will provide you with opportunities to impact ex vivo and in vivo applications by:
    • Developing, potency assays for cellular drug products, CRISPR/Cas9 components, lipid-nanoparticles, and AAV.
    • Collaborate with Intellia's cross-functional platform development team and build the bases to define and optimize and qualify potency and characterization assays.
    • Work to tech transfer assays to external testing labs.About You:
      • PhD degree in Cell Biology, Biochemistry, or related disciplines with minimum 1+ years of experience; Master's degree with minimum 5+ years of experience; BS with minimum 10+ years of experience in biotech or pharma industry with a primary focus in biologics and/or gene and cell therapy
      • In-depth knowledge of understanding the mechanism of action (MOA) of biologics and experience in design, and development of mechanism of action (MoA) reflective bioassays using appropriate technologies, such as cell-based, ELISA and enzymatic assays experience is required
      • Experience and knowledge of QC and GMP regulations is essential
      • Extensive experience in culturing cell lines as well as primary T cells, cell line development and flow cytometry are required
      • Prior experience or technical knowledge in molecular assays such as qPCR, ddPCR, NGS is desirableMeet Your Future Team: The Potency Analytical Development team is a highly motivated and lively group with an innate curiosity to learn. This team leads various important elements of the Technical Operations (CMC) department, including design of potency and characterization assays for in vivo and ex vivo drug products and drug product components.Although Intellia currently is a partially virtual environment, the Human Resources team and Cultural Ambassadors have made it a priority to continue to foster a sense of community among the group. This includes virtual happy hours, team all hands, game nights, and more! You can expect to join a hardworking, collaborative environment and to work with dedicated and team-spirited group of people. Covid-19 Vaccination Policy: All Intellia employees, regardless of work location, must be fully vaccinated for COVID-19. This requirement includes a booster dose once eligible. Requests for exemption for medical or sincerely held religious beliefs will be considered. EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Keywords: Intellia Therapeutics, Cambridge , Scientist, Analytical Development, Other , Cambridge, Massachusetts

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