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Scientist II

Company: Rangam Consultants Inc.
Location: Cambridge
Posted on: November 19, 2022

Job Description:

Precision Oncology is a dedicated Oncology Research group focused on increasing success rates in early development by applying High Content Data and Analytics to inform both Research and early Development decisions. We work as the integrated analytical arm of drug discovery teams and embrace a "Bedside to Bench and Back" approach to understand at the molecular level cancer subtypes, immune context, and drug response in patients. Molecular data (cytometric, single cell and spatial data) as well as advanced statistical and machine learning methods are used to identify targets, and animal models for hypothesis testing, POC indications, and biomarkers for advancing our cancer drug discovery programs.

We are seeking a self-motivated candidate with a strong background in immunology and flow cytometry to work in the flow center of excellence. The successful candidate we are looking for is an independent problem-solver, detail oriented and agile. Key responsibilities will include maintenance of instruments, troubleshooting instrument failures, designing, and implementing flow panels for molecular and immuno-oncology projects both independently and in collaboration with colleagues). Colleague must feel comfortable summarizing and discussing results.Key Responsibilities:

  • Design and execution of in vitro, ex vivo cellular assay and immune profiling experiments such as flow/spectral-cytometer, FACS analyzer to characterize the cellular phenotype for our project teams.
  • Develop biomarkers identification focused profiling for in vivo models
  • Maintenance and qc program on analyzers and sorters
  • Conduct training sessions and/or workshops on basic and advanced techniques for new colleagues. Assist in creating training material and user manuals.
  • Work with scientists to troubleshoot instrument issues in real time.
  • Assist scientists with sample acquisition and respond to troubleshooting requests.
  • Design and implement procedures and protocols appropriate for the management of multi-user equipment.
  • Communicate basic lab needs to leadership for both technical and administrative issues
  • Responsible for the execution and analysis of experiments.
  • Display an investigative or technological orientation in designing, executing and interpreting experiments and analytical procedures with minimal guidance.
  • Investigate basic technical problems and performs routine scientific procedures and experiments under general supervision.
  • Plan and prioritize concurrent experimental procedures.
  • Integrate, compile, and tabulate data and assist the supervisor in the analysis and interpretation of the results.Basic Qualifications:
    • Minimum of 3 years of relevant industry experience in flow cytometry
    • Hands-on experience with flow cytometers (FACSCanto II, LSRFortessa X-20, BD Symphony A5, Cytek Aurora) sorters (Sorters: Sony SH800, Sony MA900, BD FACSAria, BD FACSMelody)
    • Experience with antibody staining optimization and running profiling experiments
    • Self-motivated and organized with attention to detail and ability to multi-task
    • Excellent communication and time-management skills
    • Strong written and spoken English skills
    • Familiarity with common computer programs (MS Word, Excel and PowerPoint)
    • Attention to detail and organization
    • Motivated self-starter
    • Good problem-solving abilitiesPreferred Qualifications:
      • Experience with multiple FACS software (flowjo, FCExpress, Fluorofinder)
      • Experience sorting cells on Sony or BD instrumentsMust Have:
        • Flow CytometryExperience as is relates to:
          • Must have the Ability to sort cells o Trouble shooting Cytometers and working with Vendors
          • Must have experience with multiple types of flow cytometers

Keywords: Rangam Consultants Inc., Cambridge , Scientist II, Other , Cambridge, Massachusetts

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