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Scientific Investigator - Human Genetics (US)

Company: GlaxoSmithKline
Location: Cambridge
Posted on: August 4, 2022

Job Description:

Site Name: USA - Pennsylvania - Upper Providence, USA - Massachusetts - Cambridge Posted Date: Apr 21 2022 We are seeking several talented and motivated statistical geneticists to join our expanding Human Genetics team within the Genomic Sciences department at GSK. The selected candidates will focus on the development, validation, and implementation of statistical genetics methods for the identification of genetically validated drug targets. The work will include analyses of datasets of millions of genotyped individuals linked to detailed phenotyping, as well as integration of those data with growing functional genomics evidence to generate biological insights that will be translated to support development of innovative new medicines for patients. At the core of GSK's R&D strategy is our aim to leverage major scientific and technological advances, including investment in biobanks linked to large-scale human health databases; cutting-edge informatics platforms; human genetics, functional genomics, and AI/ML capabilities; and leading industry-academia partnerships (e.g., 23andMe, UK Biobank, FinnGen, Broad Institute, Laboratory of Genomic Research and Altius Institute of Biomedical Sciences), to identify the best targets with strong evidence of their causal role in disease biology. The successful candidates will work in a multidisciplinary, collaborative and scientifically driven environment, interacting with GSK scientists and key academic collaborators to advance drug discovery and clinical development in multiple disease areas. They will perform field-leading research to address important drug discovery and development challenges, directly impact GSK's R&D pipeline, and publish results in top scientific journals. Location: the position can be filled at any of our research locations, Stevenage, UK Cambridge, MA, US Upper Providence, PA, US The selected Statistical Genetics Investigator will: Implement approaches to acquire, analyse, interpret, and apply human genetic evidence to inform target selection and validation decisions across a range of disease areas. Participate in project teams with GSK scientists and external collaborators. Find creative solutions and quickly prototype applications to address challenging scientific questions. Work within therapeutic aligned matrix teams and in close collaboration with biologists, geneticists, genomic experts, and computational biologists. Enjoy working in a delivery-focused team at the forefront of GSK R&D strategy, where their work will directly contribute to identification of the next generation of medicines. Basic qualifications: Ph.D., or equivalent experience, in statistical genetics, genetic epidemiology, statistical bioinformatics, human genetics, immunology, or biomedical sciences. Experience with approaches used to understand complex disease genetics, e.g., genome-wide association analysis, rare-variant analysis, fine-mapping, Mendelian randomisation, LD Score regression and cross-trait analysis. Experience with command line interface and working in high performance computing environments, and at least one general purpose programming language (e.g., R or Python). Experience in integration and interpretation of genetic and functional genomics data to investigate potential causal mechanisms in disease with publications in peer reviewed journals. Preferred qualifications: Excellent communication and influencing skills as well as developing leadership skills for working with multidisciplinary teams and with international colleagues. Familiarity with modern high-throughput functional genomics technologies and data, including epigenomics and transcriptomics, single cell omics and CRISPR. Experience analysing data from both array genotyping and next generation sequencing platforms. Familiarity with the principles of drug discovery and the identification of new drug targets. Demonstrable teamwork skills to find creative solutions to scientific questions. Research experience in characterising the genetic architecture of complex diseases. In R&D At GSK, we want to find new medicines and vaccines in ways that are faster, more effective and more predictable. We start with what matters most, the science. Our approach to R&D focuses on science related to the immune system, the use of human genetics, and advanced technologies. Our pipeline currently comprises of more than 60 vaccines and medicines across four core therapeutic areas including oncology, infectious diseases, immunology / respiratory and HIV. We have pivotal study starts in 2021 for our RSV vaccine in older adults, COVID-19 assets, long-acting anti-IL-5 antagonist, daprodustat, and dostarlimab. In oncology, momentum is building with 15 potential medicines in trials, including nine immuno-oncology and three cell therapies. We give our scientists the freedom to own the process. Our scientists often use genetic data to help us understand the root cause of disease. We steer the research where the data shows we can do most good. If a project doesn't pan out, we take what we've learned and apply it elsewhere. Technology can help us find patterns in genetic data better and faster. We're using machine learning to unlock the potential of complex genetic data with new levels of speed, precision, and scale. And we're one of the first biopharmaceutical companies to have created an in-house AI lab dedicated to drug development. Even with the knowledge, tools, and resources within GSK, there's always a benefit to new perspectives. That's why we're increasingly partnering with and hiring outstanding people from cutting edge fields like tech, data-science and academia. In 2018, GSK formed an exclusive, highly innovative collaboration with 23andMe, the world's leading consumer genetics and research company. Other partners include: the Altius Institute; the UK Biobank, which is generating anonymized genetic sequence data from 500,000 volunteers; and the Open Targets Consortium, the mindset and approach of smaller, more agile startups. Find out more: Our approach to R&D. Why GSK? At GSK, we have delivered unprecedented change over the past four years - to improve R&D productivity and performance, transform commercial execution and to, strengthen our leadership and reshape our organisation. Now, we're getting ready to deliver the most significant change to our company in over 20 years. We're on track to separate and create two ambitious new companies in 2022: A new GSK with a leading portfolio of vaccines, specialty and general medicines, and R&D based on the science of the immune system and genetics; and a new world-leading consumer healthcare company built on brands and innovation and delivering better everyday health. With new ambition comes new purpose. GSK will unite science, talent, and technology to get ahead of disease together. We'll be a company where outstanding people thrive, delivering strong, sustainable returns to our shareholders and with the power to improve the health of more than 2.5 billion people over the next 10 years. All of this depends on our people and our culture. A culture that is ambitious for patients - so we deliver what matters better and faster; where we are all accountable for our impact and supported to succeed; and where we do the right thing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together. LI-GSK If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or 1 801 567 5155 (outside US). GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class. At GSK, the health and safety of our employees are of paramount importance. As a science-led healthcare company on a mission to get ahead of disease together, we believe that supporting vaccination against COVID-19 is the single best thing we can do in the US to ensure the health and safety of our employees, complementary workers, workplaces, customers, consumers, communities, and the patients we serve. GSK has made the decision to require all US employees to be fully vaccinated against COVID-19, where allowed by state or local law and where vaccine supply is readily available. The only exceptions to this requirement are employees who are approved for an accommodation for religious, medical or disability-related reasons. Important notice to Employment businesses/ Agencies GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site. Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting For the Record site.PDN-961eeac7-6536-4240-a88f-db710856baf4

Keywords: GlaxoSmithKline, Cambridge , Scientific Investigator - Human Genetics (US), Other , Cambridge, Massachusetts

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