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Sr. Scientist

Company: Bristol-Myers Squibb
Location: Cambridge
Posted on: August 3, 2022

Job Description:

At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science. -In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference. Summary Bristol Myers Squibb is a global biopharmaceutical company whose mission is to discover, develop and deliver innovative medicines that help patients prevail over serious diseases. One shared journey is moving us forward at Bristol Myers Squibb. Around the world, we are passionate about making an impact on the lives of patients with serious disease. Empowered to apply our individual talents and ideas so that we can learn and grow together. Driven to make a difference, from innovative research to hands-on community support. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives. Job Description We seek an experienced, talented, highly motivated and detail-oriented Proteomics Researcher with proven track record to join the Discovery & Translational Proteomics group within the Research & Early Development organization at BMS. This is a laboratory based position, reports directly to the Head of Discovery & Translational Proteomics within the Small Molecule Drug Discovery organization. The candidate is expected to work effectively in a highly collaborative matrixed environment and interface with Oncology, Immunoscience, Neuroscience, Cardiovascular, and Fibrosis discovery biology areas, chemistry as well as translational research investigators and champion proteomics methodologies / modalities to help solve complex drug discovery & translational research questions. - The candidate needs to have sufficiently deep understanding of biochemistry, medicinal chemistry and chemical biology to help articulate the problem statement, communicate with key stakeholders and bridge across matrixed teams. - - A demonstrated ability to convert datasets to usable knowledge and utilize it to support the program progression across the Drug Discovery and Translational Research continuum. - - Deep familiarity with other "omics" and experience in building synergies to achieve integrative omics outcomes. - An established track record in articulating the need for proteomics as well as successfully applying proteomics to drug discovery and translational space. - A demonstrated ability in applying activity-based and chemical proteomics to elucidate receptor ligand interactions, target deconvolution, drug-proteome interactions for, specificity as well as on/off target assessments and modulation protein-protein interactions with chemotype intervention. - Experience developing, deploying and utilizing innovative proteomics techniques / workflows (emphasis on Chemical Proteomics) to characterize complex proteomes (including post-translational proteomes) to enable discovery, translational activities is absolutely necessary. - Experience with proteome level post-translational modification analyses (e.g. glycosylation, acetylation/methylation) is highly desirable. - Hands on" experience with proteomics analytical instrumentation (latest generation, nano-chromatography and mass spectrometry), associated workflows, and data processing software packages is a must. - The candidate is expected to spend at least 60%-70% of their time in the proteomics lab and perform experiments alongside their team as well as interface with the larger proteomics team. - - Significant experience and in-depth knowledge of proteomics design of experiments, LC/MS proteomics data processing and subsequent data analyses. Detailed understanding of proteomics related bioinformatics and associated software packages is required. - Experience and ability to successfully interface with bioinformaticians and biostatisticians is an absolute must to enable in-depth proteomics data analysis and achieve superlative outcomes for programs. - Hands on experience with automation and laboratory instrument data management would is highly desirable. - Proficiency in applying classical protein biochemical techniques (protein fractionations, chromatography etc.) and most up to date proteomics techniques is expected and familiarity with basic cell culture techniques and standard molecular biology techniques is highly desirable. - - Additionally, experience with handling human as well as animal biomatrices (including tissues, plasma ---) is highly desirable. - Overall, excellent lab skills and lab etiquette are crucial and required to be successful in this position. - The candidate must have expertise with compiling and reviewing lab work practices and maintain regular scientific records in terms of laboratory notebooks. - The candidate should be proficient with workplace software tools (word processing, excel, presentation etc.). Qualifications - Ph.D. (minimum of 4-6 yrs) in Chemistry, Biochemistry, Analytical Chemistry or related field is preferred including relevant proteomics experience. - Scientific creativity, innovation and resilience are absolutely necessary to be successful in this position. - A track record of scientific productivity in proteomics area documented in high impact peer reviewed journals is necessary. - A demonstrated ability to manage teams and contribute strategically to areas of discovery & translational research. - - -The candidate should have a strong interest in drug discovery, translational, and clinical research. Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. - Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture. To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S. Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to . Visit to access our complete Equal Employment Opportunity statement. Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

Keywords: Bristol-Myers Squibb, Cambridge , Sr. Scientist, Other , Cambridge, Massachusetts

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