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Senior Research Associate, Analytical Development (CMC)

Company: Carmine Therapeutics, Inc.
Location: Cambridge
Posted on: June 25, 2022

Job Description:

Senior Research Associate, Analytical Development (CMC) Job Location Cambridge, MA Description Carmine Therapeutics is pioneering a powerful new class of gene therapy based on engineered red blood cells extracellular vesicles (RBCEVs). Carmines proprietary Gene Therapy platform is well-positioned to address the unmet needs in the delivery of next-generation therapeutic modalities to millions of patients. Founded by Esco Ventures and Professors Harvey Lodish, Minh Le and Jiahai Shi, Carmines proprietary Red Cell EV Gene Therapy (REGENT) platform has the potential to overcome the most critical shortcomings of viral-based gene therapy vectors. The companys non-immunogenic system has already demonstrated the ability to deliver payloads over 30 kb, and to boost transgene expression through re-dosing. Carmine was awarded the 2019 Bristol-Myers Squibbs Golden Ticket to LabCentral (Cambridge, MA) and has established an extensive research collaboration with Takeda Pharmaceuticals. Carmine was also recognized as one of Fierce Biotechs Fierce15 biotech companies of 2020. Our company is well-situated in developing next-generation non-viral gene therapies to overcome the limitations of AAV-based gene therapy. Carmine is well-capitalized and headquartered in Cambridge, MA, with a location in Singapore. The CMC Team in Cambridge is looking for a Senior Research Associate to work in the Analytical Development team to implement liquid chromatography-based analytical techniques for RBCEVs. Reporting to the Associate Director of Analytical Development, this position will have high visibility in collaborating with the Research team to characterize high-priority samples going into in vivo studies, and will expand in scope as additional assays are developed for product characterization in later stages of development. Responsibilities Execute analytical methods for the characterization of loaded and unloaded RBCEVs Generate, interpret, and analyze data Contribute to analytical method qualification/validation Collaborate with cross-functional teams Participate in presentations, reports, patent filings, and external communications Support the continued creation and expansion of the companys intellectual property Requirements An analytical development scientist with an MS in Chemistry, Biochemistry, Chemical Engineering, or a related scientific discipline and 1-2 years of experience in an industry setting, or a BA with 3-5 years of experience in an industry setting Experience with liquid chromatography assays is required Cross-functional interaction with the Research group for data interpretation is an essential component of this role Experience in the following would be an asset: Methods for nanoparticle analysis and counting, qPCR/ ddPCR Willingness to explore and learn new analytical methods Knowledge of gene therapy/nucleic acid delivery/extracellular vesicles is an advantage

Keywords: Carmine Therapeutics, Inc., Cambridge , Senior Research Associate, Analytical Development (CMC), Other , Cambridge, Massachusetts

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