Posted on: June 25, 2022
Developing innovative therapies is one of the most challenging,
most essential, and personally rewarding fields in science. This is
the most exciting time to be a part of Astellas, a company with a
uniquely collaborative and patient-focused culture.
There's something special about working at Astellas. It's reflected
in our focus on the people we serve, the way we treat each other
and the results we achieve together as a company. Astellas is
announcing a Scientist I, Translational Sciences opportunity based
out of the Mitobridge site in Cambridge, MA.
The primary focus of this Scientist I position is to design and
conduct experiments in the laboratory to advance and support
autophagy and Calcium projects in the early discovery pipeline.
Additional responsibilities include partnering across research
divisions, working collaboratively with both internal and external
experts and to identify ways to advance early-stage drug discovery
programs. Individual must be highly motivated, capable of working
with multidisciplinary research teams and have a demonstrated track
record of success in independent scientific research. The
successful candidate will be an outstanding scientist with strong
conceptual and practical experience in the following areas:
Biochemistry, Cell biology and Molecular biology.
Essential Job Responsibilities:
- Design, develop and validate biochemical, biophysical,
molecular biology and cell biology experiments to support various
needs of the multiple discovery projects.
- Independently trouble shoot experiments to optimize the assays
- Develop novel cellular disease models to explore the
- Provide scientific guidance in designing and implementing cell
biology, in vivo pharmacology, and biomarker related studies.
- Contribute to target and indication selection for different
programs in the company
- Work with external CROs and academic laboratories - establish
new partnerships and manage the existing ones.
- Analyze, interpret, and summarize the experiment data both in
written and oral reports. Effectively draw conclusions from the
results and define next steps. Maintain a detailed lab notebook.
Present the program updates to diverse set of audience.
- Work in a fast-paced environment and meet the goals in the
targeted time frame.
- Keep abreast of emerging developments in the fields of various
biology like Autophagy, Calcium signaling and Mitochondrial biology
that would advance the existing programs and identification of new
- Collaborate with diverse project teams internally and
externally to advance the programs.Qualifications:
- PhD. with 0-3 years, MS with 6+ years or BS with 8 + years of
highly relevant assay development experience in a biopharmaceutical
- Extensive experience in biochemical & cell-based assay
development and optimization.
- Strong knowledge on various cell signaling pathways especially
in protein degradation and mitochondrial signaling.
- Highly organized, self-motivated, results driven and a
- Demonstrated creativity and novel approaches to solving
- Highly independent thinker with the ability to translate
abstract concepts and complexity into actionable solutions.
- Knowledge of small molecule drug discovery.
- Experience presenting the scientific data and concepts to
diverse set of audience.
- Strong leadership, interpersonal and communication skills with
an enthusiasm for participating in a fast-paced environment
characterized by rigorous science and innovative
- In-depth knowledge of protein homeostasis
- Experience in small molecule drug discovery
- Deep understanding and experience of using in vivo disease
models from rodents to non-human primates and human disease
- Experience working within large pharma organizations and/or
biotech/start up environment#LI-KW1
Equal Opportunity Employer Minorities/Women/Protected
Keywords: Astellas, Cambridge , Scientist I, Other , Cambridge, Massachusetts
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