Principal Scientist Discovery Pharmacology and In Vivo Biology
Company: Bristol-Myers Squibb
Location: Cambridge
Posted on: June 24, 2022
Job Description:
At Bristol Myers Squibb, we are inspired by a single vision -
transforming patients' lives through science. -In oncology,
hematology, immunology and cardiovascular disease - and one of the
most diverse and promising pipelines in the industry - each of our
passionate colleagues contribute to innovations that drive
meaningful change. We bring a human touch to every treatment we
pioneer. Join us and make a difference. We are seeking a highly
motivated and creative Principal Scientist to be part of the
Oncology Discovery Pharmacology and In Vivo Biology Group at the
Mechanisms of Cancer Resistance Thematic Research Center at
Bristol-Myers Squibb in Cambridge, MA. The candidate will aide in
the discovery and advancement of novel therapeutics for the
treatment of cancer leveraging both cancer intrinsic and immune
intrinsic biology. The qualified candidate will possess the ability
to work across a highly matrixed environment to advance drug
discovery programs from hit to lead identification/lead
optimization to IND enabling activities and ultimately to Proof of
Concept in patients. The candidate will be responsible for
developing and executing in vivo strategies using a wide range of
animal models including syngeneic, GEMM, CDX, and PDX tumor models.
The candidate will lead in vivo pharmacology efforts in
multi-disciplinary drug discovery teams and will be expected to
work seamlessly with colleagues across BMS Thematic Research
Centers and collaborators in medicinal chemistry, MAP/DMPK,
preclinical safety, translational research, and early clinical
development. The successful candidate will also be expected to
leverage his/her experience and skills to train and manage a small
team of research scientists. - Job Qualifications and
Requirements
- PhD in cancer biology with at least 4 years of relevant
industry experience and demonstrated expertise in cancer biology
and oncogenic signaling pathways.
- Industry experience with demonstrated ability developing
focused in vivo strategies and utilizing PK/PD/efficacy data to
drive small molecule lead optimization & characterization as well
as translational strategies to enable early clinical development is
required.
- Experience in using various cell line xenograft, PDX and
syngeneic mouse models is desired.
- Demonstrated expertise in ex vivo pharmacodynamic assays
including qPCR, quantigene, MSD/ELISA and flow cytometry.
- The ability to manage a small laboratory group is expected,
including providing growth and development opportunities for direct
reports.
- Excellent interpersonal and communication skills with the
ability to interact effectively with internal and external
colleagues is required. -
- Competitive candidates are expected to have a strong track
record of independent and innovative research as evidenced by
publications in top tier peer-reviewed journals. Job
Responsibilities include
- Function as Pharmacology lead for multiple drug discovery
programs . Working closely with project teams and key stakeholders,
lead the development of in vivo strategies from target concept to
Proof of Concept in patients, including target validation, lead
optimization & characterization, and development of translational
strategies.
- Develop novel animal models that more closely mimic human
cancer to enable the discovery of novel biology, answer mechanistic
questions and screen/profile drug candidates. -
- Work closely with colleagues in Translational Research and
Early Clinical Development to establish biomarker strategies and to
develop preclinical data sets to inform patient stratification and
rational combination strategies for novel therapeutics.
- Serve as oncology biology and drug discovery expert on external
collaborations and alliances.
- Manage and provide mentorship to direct reports, research
scientists and associates in the team.
- Work as a member of a diverse and motivated team of researchers
from across Discovery Oncology and key internal and external
collaborators. - Around the world, we are passionate about making
an impact on the lives of patients with serious diseases. Empowered
to apply our individual talents and diverse perspectives in an
inclusive culture, our shared values of passion, innovation,
urgency, accountability, inclusion and integrity bring out the
highest potential of each of our colleagues. Bristol Myers Squibb
recognizes the importance of balance and flexibility in our work
environment. We offer a wide variety of competitive benefits,
services and programs that provide our employees with the resources
to pursue their goals, both at work and in their personal lives. -
Physical presence at the BMS worksite or physical presence in the
field is an essential job function of this role which the Company
deems critical to collaboration, innovation, productivity, employee
well-being and engagement, and enhances the Company culture. To
protect the safety of our workforce, customers, patients and
communities, the policy of the Company requires all employees and
workers in the U.S. and Puerto Rico to be fully vaccinated against
COVID-19, unless they have received an exception based on an
approved request for a medical or religious reasonable
accommodation. Therefore, all BMS applicants seeking a role located
in the U.S. and Puerto Rico must confirm that they have already
received or are willing to receive the full COVID-19 vaccination by
their start date as a qualification of the role and condition of
employment. This requirement is subject to state and local law
restrictions and may not be applicable to employees working in
certain jurisdictions such as Montana. This requirement is also
subject to discussions with collective bargaining representatives
in the U.S. Our company is committed to ensuring that people with
disabilities can excel through a transparent recruitment process,
reasonable workplace adjustments and ongoing support in their
roles. Applicants can request an approval of accommodation prior to
accepting a job offer. If you require reasonable accommodation in
completing this application or if you are applying to a role based
in the U.S. or Puerto Rico and you believe that you are unable to
receive a COVID-19 vaccine due to a medical condition or sincerely
held religious belief, during or any part of the recruitment
process, please direct your inquiries to adastaffingsupport@bms.com
. Visit careers.bms.com/eeo-accessibility to access our complete
Equal Employment Opportunity statement. Any data processed in
connection with role applications will be treated in accordance
with applicable data privacy policies and regulations.
Keywords: Bristol-Myers Squibb, Cambridge , Principal Scientist Discovery Pharmacology and In Vivo Biology, Other , Cambridge, Massachusetts
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