Analytical Scientist

Company: Orum Therapeutics
Location: Cambridge
Posted on: June 24, 2022

Job Description:

Orum Therapeutics is seeking to expand our in-house analytical capabilities to help advance quality compounds toward the clinic. The successful candidate will have a strong background in LC-MS antibody/protein characterization or bioanalytical quantitation and a passion for driving high-impact projects in the anti-cancer drug discovery space. The candidate will conduct bench-based research focused on sample preparation, LC-MS and HPLC analytical characterization/quantitation for ADC, Antibody, small molecule drug, data analysis and report within a dynamic, enthusiastic, highly interdisciplinary and collaborative team.Principle Duties and Responsibilities--- Perform LC-MS characterization of ADC, antibody and small molecule drug to support Chemistry discovery and development including: intact mass analysis, deglycosylation and reduction LC-MS, DAR measurement, peptide mapping, PTM profiling, native MS, structural characterization for small molecule drugs.--- Identify metabolites of ADC from in vivo or in vitro samples with LC-MS technology--- Characterize ADC and antibody using HPLC methodology (SEC, HIC, IEX, RP etc), plus method development--- Instrument operation, maintenance and troubleshooting for Thermo Vanquish UHPLC-Orbitrap MS, Waters Acquity UPLC-SQD MS, and Agilent HPLC--- Prepare samples to be tested by LC-MS and LC-MS/MS from various sources, i.e., purified protein products, biological matrix (plasma, serum and tissues, etc)--- Present written and oral reports to multidisciplinary team--- Enter all data into electronic laboratory notebooks and database daily, generate weekly summary reports for management review--- Identify and integrate technologies that improve or expand the ability to LC-MS and HPLC analysis by working with teammates, collaborators, vendors, and staying abreast of the literature--- Contribute to the build-out and upkeep of an expanding laboratory through maintaining shared equipment, assisting with general laboratory housekeeping, and developing processes for improving workflow efficiencySkills, Abilities & Competencies--- Essential to possess technical expertise in the LC-MS analysis of proteins or small molecules, which may be one from protein or small molecule characterization, protein bioanalytical quantitation or proteomics.--- Hands-on experience necessary, including sample preparation (deglycosylation, reduction, and in-solution/in-gel digestion), LC-MS operation, basic maintenance and troubleshooting, HPLC (SEC, HIC, IEX, RP etc)--- Nice to have skills: extraction and enrichment techniques (Affinity Capture, SPE, Protein Precipitation), CE-SDS, cIEF, DLS, DSC, SDS-PAGE etc;--- A track record of innovation and scientific rigor, strong problem solving and troubleshooting skills, and ability to contribute constructively to discussions--- Goal oriented, organized, capable of prioritizing and working on multiple projects, and able to help others--- Good verbal and written communication skills--- Enthusiasm for collaborating with multidisciplinary teams of chemists, protein engineers, and biologists--- Proficiency with operating common laboratory equipment and maintaining laboratory infrastructureEducation- Ph. D in Chemistry or Biochemistry or a relevant scientific discipline with 1+ year experience (postdoc or industry) for therapeutic protein LC-MS analysis, Master with 3+ year of industry experienceOrum offers a Core benefits program which includes: medical, dental, short and long term disability, life insurance and a 401k.*U.S. citizens and those authorized to work in the U.S. (green card) are encouraged to apply. We are unable to sponsor at this time.*Candidate must be able to pass a background investigation.*Unable to work with 3rd party candidates or agencies.To perform this job successfully, an individual must be able to perform each essential duty satisfactorily within the context of the representative work environment and physical demands described above. Likewise, qualifications listed are representative of the knowledge, skills, and abilities required to perform the position's essential functions. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.Orum Therapeutics is an Equal Opportunity Employer (EOE). -

Keywords: Orum Therapeutics, Cambridge , Analytical Scientist, Other , Cambridge, Massachusetts