Analytical Scientist
Company: Orum Therapeutics
Location: Cambridge
Posted on: June 24, 2022
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Job Description:
Orum Therapeutics is seeking to expand our in-house analytical
capabilities to help advance quality compounds toward the clinic.
The successful candidate will have a strong background in LC-MS
antibody/protein characterization or bioanalytical quantitation and
a passion for driving high-impact projects in the anti-cancer drug
discovery space. The candidate will conduct bench-based research
focused on sample preparation, LC-MS and HPLC analytical
characterization/quantitation for ADC, Antibody, small molecule
drug, data analysis and report within a dynamic, enthusiastic,
highly interdisciplinary and collaborative team.Principle Duties
and Responsibilities--- Perform LC-MS characterization of ADC,
antibody and small molecule drug to support Chemistry discovery and
development including: intact mass analysis, deglycosylation and
reduction LC-MS, DAR measurement, peptide mapping, PTM profiling,
native MS, structural characterization for small molecule drugs.---
Identify metabolites of ADC from in vivo or in vitro samples with
LC-MS technology--- Characterize ADC and antibody using HPLC
methodology (SEC, HIC, IEX, RP etc), plus method development---
Instrument operation, maintenance and troubleshooting for Thermo
Vanquish UHPLC-Orbitrap MS, Waters Acquity UPLC-SQD MS, and Agilent
HPLC--- Prepare samples to be tested by LC-MS and LC-MS/MS from
various sources, i.e., purified protein products, biological matrix
(plasma, serum and tissues, etc)--- Present written and oral
reports to multidisciplinary team--- Enter all data into electronic
laboratory notebooks and database daily, generate weekly summary
reports for management review--- Identify and integrate
technologies that improve or expand the ability to LC-MS and HPLC
analysis by working with teammates, collaborators, vendors, and
staying abreast of the literature--- Contribute to the build-out
and upkeep of an expanding laboratory through maintaining shared
equipment, assisting with general laboratory housekeeping, and
developing processes for improving workflow efficiencySkills,
Abilities & Competencies--- Essential to possess technical
expertise in the LC-MS analysis of proteins or small molecules,
which may be one from protein or small molecule characterization,
protein bioanalytical quantitation or proteomics.--- Hands-on
experience necessary, including sample preparation
(deglycosylation, reduction, and in-solution/in-gel digestion),
LC-MS operation, basic maintenance and troubleshooting, HPLC (SEC,
HIC, IEX, RP etc)--- Nice to have skills: extraction and enrichment
techniques (Affinity Capture, SPE, Protein Precipitation), CE-SDS,
cIEF, DLS, DSC, SDS-PAGE etc;--- A track record of innovation and
scientific rigor, strong problem solving and troubleshooting
skills, and ability to contribute constructively to discussions---
Goal oriented, organized, capable of prioritizing and working on
multiple projects, and able to help others--- Good verbal and
written communication skills--- Enthusiasm for collaborating with
multidisciplinary teams of chemists, protein engineers, and
biologists--- Proficiency with operating common laboratory
equipment and maintaining laboratory infrastructureEducation- Ph. D
in Chemistry or Biochemistry or a relevant scientific discipline
with 1+ year experience (postdoc or industry) for therapeutic
protein LC-MS analysis, Master with 3+ year of industry
experienceOrum offers a Core benefits program which includes:
medical, dental, short and long term disability, life insurance and
a 401k.*U.S. citizens and those authorized to work in the U.S.
(green card) are encouraged to apply. We are unable to sponsor at
this time.*Candidate must be able to pass a background
investigation.*Unable to work with 3rd party candidates or
agencies.To perform this job successfully, an individual must be
able to perform each essential duty satisfactorily within the
context of the representative work environment and physical demands
described above. Likewise, qualifications listed are representative
of the knowledge, skills, and abilities required to perform the
position's essential functions. Reasonable accommodations may be
made to enable individuals with disabilities to perform the
essential functions.Orum Therapeutics is an Equal Opportunity
Employer (EOE). -
Keywords: Orum Therapeutics, Cambridge , Analytical Scientist, Other , Cambridge, Massachusetts
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