Scientist

Company: Marengo Therapeutics
Location: Cambridge
Posted on: June 22, 2022

Job Description:

Company Overview
Marengo Therapeutics, is pioneering first-in-class therapeutics that activate the right immune response to promote lifelong protection against cancer. Marengo has uncovered a novel approach to T cell activation by targeting V-- TCR chain to unleash rapid, potent, and long-lasting anti-tumor immune responses in a safe and effective way. We're leveraging our versatile, proprietary bispecific fusion protein platform to selectively deliver the right activation to the right T cell subsets, customizable to patient needs with its tunable properties, with an initial focus on advanced solid tumors and broad applicability beyond.
Marengo is driven by core values that guide our company's mission and approach from the inside out: we demonstrate unparalleled commitment to patients and their loved ones, we are confident in our science and our team, we operate with courage, and we creatively apply deep expertise to new ways of thinking with curiosity and imagination. With an exciting journey ahead and a tremendous opportunity for growth, now is the time to join the Marengo team and make an impact on cancer patient care - are you ready to join the new frontier?
Job SummaryMarengo is seeking an exceptional Scientist to join our team. Reporting to the Head of Antibody Discovery and Protein Sciences (ADPS) the individual will contribute significantly to a small, rapidly expanding company offering opportunity to advance projects while improving the lives of patients.
We are seeking an experienced, versatile and self-driven individual to our growing team of energetic scientists. This is a unique opportunity to collaborate with colleagues in Discovery and Early Development teams to directly contribute to discovering novel IO therapeutics. This individual will play a key role in the design and optimization of our next-generation biologic therapeutics, with a focus on fusion proteins and antibodies. The successful candidate will have a demonstrated in-depth understanding of advanced antibody analytics as applied to assessment of developability of Antibody-derived multi-specific therapeutics and excel in a fast-paced environment. The candidate will be responsible for advanced lab activities and is expected to impact at the organizational level in a matrix team environment.

Responsibilities and Duties

• Carry out hands-on lab work to express and purify novel protein therapeutics to support antibody screening and lead optimization in discovery programs
• Demonstrate a thorough understanding of advanced protein analytical assays. Apply a broad range of protein analytics to assess and optimize the developability features of multi-specific therapeutics. Develop new analytical methods as required to enhance the analytical toolbox and capabilities.
• Develop a thorough understanding of the molecular formats used in Discovery programs
• Interpret data and design production and analytical strategies to understand and troubleshoot potential challenges associated with novel molecular formats
• Act as a Subject Matter Expert in Antibody production and analytics and provide guidance to the research project teams
• Manage several projects simultaneously and act as single point of accountability on projects
• Analyze and present data, both in written reports and oral presentations
• Effectively manage projects and resources to maximize progress
• Manage collaborations with external CROs
• Exhibit versatility to take on new responsibilities within ADPS group
• Maintain detailed lab notebooks
  
  Qualifications and Skills
  - PhD in Biochemistry, Molecular or Structural Biology or a closely related field and extensive experience in antibody generation and bioanalytical characterization is required - Prior experience in pharma or biotech is highly preferred - Experience in production of complex Antibody-derived biologics using mammalian host systems and purification using a wide range of AKTA systems - Experience in protein analytics including but not limited to stability assessment (DSC, DSF), mass spec, HPLC (SEC, HIC), capillary gel electrophoresis (CE-SDS, cIEF) - Experience in engineering molecular formats using structure-guided design approach is a plus - Experience working in a matrix environment - Attention to detail and a creative approach mentality to problem solving - Highly analytical mind, attention to detail, and organizational skills are critical - Self-motivated with a strong sense of responsibility, integrity, and a collaborative spirit - Ability to work independently to design and troubleshoot experiments - Versatile and quick learner to take on new responsibilities and implement new technologies

Keywords: Marengo Therapeutics, Cambridge , Scientist, Other , Cambridge, Massachusetts