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Scientist, Bioassays, Analytical Development (CMC)

Company: Carmine Therapeutics
Location: Cambridge
Posted on: June 22, 2022

Job Description:

Carmine Therapeutics is pioneering a powerful new class of gene therapy based on engineered red blood cells extracellular vesicles (RBCEVs). Carmine's proprietary Gene Therapy platform is well-positioned to address the unmet needs in the delivery of next-generation therapeutic modalities to millions of patients. Carmine was awarded the 2019 Bristol-Myers Squibb's Golden Ticket and has established an extensive research collaboration with Takeda Pharmaceuticals. Carmine was also recognized as one of Fierce Biotech's Fierce15 biotech companies of 2020. Our company is well-situated in developing next-generation non-viral gene therapies to overcome the limitations of AAV-based gene therapy.Carmine is based in Cambridge, MA, and Singapore. Please note we are only seeking candidates in the Boston area and will not be relocating anyone at this time.Scientist, Bioassays, Analytical Development (CMC)The CMC Team in Cambridge is looking for a Scientist to work in the Analytical Development team to design and implement ELISA and ddPCR-based analytical techniques for RBCEVs. Reporting to the Associate Director of Analytical Development, this position will have high visibility in collaborating with the Research team to characterize high-priority samples going into in vivo studies and developing additional assays for product characterization in later stages of development.Responsibilities

  • Design and execute ELISA-based and ddPCR-based analytical methods for the characterization of loaded and unloaded RBCEVs
  • Mentor junior colleagues concerning assay development and data interpretation
  • Generate, interpret, and analyze data
  • Contribute to analytical method qualification/validation
  • Collaborate with cross-functional teams
  • Participate in presentations, reports, patent filings, and external communications
  • Support the continued creation and expansion of company's intellectual propertyExperience & Qualifications
    • An analytical development scientist with Ph.D. in Chemistry, Biochemistry, Chemical Engineering, or a Master's degree in Chemistry, Biochemistry, Chemical Engineering and 5-7 years of experience in an industry setting, or a Bachelor's degree with 10+ years of experience in an industry setting
    • Experience with ELISA assay development in a variety of detection formats and ddPCR assay development are both required
    • Cross-functional interaction with the Research group for data interpretation and initial assay transfer is an essential component of this role
    • Willingness to explore and learn new analytical methods
    • Knowledge of gene therapy/nucleic acid delivery/extracellular vesicles is an advantage
    • Team oriented and highly motivated

Keywords: Carmine Therapeutics, Cambridge , Scientist, Bioassays, Analytical Development (CMC), Other , Cambridge, Massachusetts

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