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Principal Scientist, Discovery

Company: Jounce Therapeutics, Inc.
Location: Cambridge
Posted on: June 19, 2022

Job Description:

Role Description:We are looking for a highly motivated scientist to join the Discovery Immuno-Oncology group at Jounce Therapeutics. The successful candidate for this position will play a leading role within our team of scientists engaged in the discovery and testing of novel cancer immunotherapeutic biologics. Direct program leadership of one or more discovery programs including managing timelines, driving key go/no-go decision making, communication of program strategy and progress, contributing to regulatory filings, and management of direct reports are key elements of this position. The candidate must be capable of working effectively across functional groups and possess well developed oral and written communication skills. If you're a highly motivated self-starter, capable of working effectively as both a team leader and Discovery team member, this could be a great role for you! Responsibilities:

  • Leadership of one or more discovery programs;
  • Provision of both immuno-oncology guidance and technical expertise to a cross-functional team;
  • Presentation of program strategy and progress to research leadership and senior management teams;
  • Contribute broadly to the success of the Discovery portfolio by sharing of data, expertise and constructive feedback across project teams.
  • Drafting of documents to support regulatory filings;
  • Preparation of data for presentation at external scientific meetings, and for publication in peer-reviewed journals; and
  • Direct management of a Discovery-based team (-3-5 FTEs) along with matrixed management of program team members.
    • Ph.D. or equivalent in Immunology or Cancer Immunology with 5+ years industry experience;
    • Strong background in immunology with an excellent understanding of the role of immune cells in influencing cellular adaptive and innate immune responses, and experience in advancing early target programs in an industry setting;
    • Experience in leading and managing both direct reports and/or matrixed resources on multi-disciplinary project teams;
    • Well-developed ability to define critical path and effectively drive a program towards key decision points;
    • Demonstrated ability to think creatively and critically to make a measurable impact on projects;
    • Ability to thrive in a highly collaborative, fast-paced, team-oriented environment with colleagues from diverse disciplines;
    • Demonstrated scientific impact as measured by publications in top tier journals, and/or patents;
    • Excellent organizational, communication and presentation skills; and
    • Strong interpersonal skills and a desire to bring novel therapeutics to patients.
      About Jounce TherapeuticsJounce Therapeutics, Inc. is a clinical-stage immunotherapy company dedicated to transforming the treatment of cancer by developing therapies that enable the immune system to attack tumors and provide long-lasting benefits to patients through a biomarker-driven approach. Jounce currently has multiple development stage programs ongoing while simultaneously advancing additional early-stage assets from its robust discovery engine based on its Translational Science Platform. Jounce's highest priority program, JTX-8064, is a LILRB2 (ILT4) receptor antagonist shown to reprogram immune-suppressive tumor associated macrophages to an anti-tumor state in preclinical studies. A Phase 1 clinical trial, named INNATE, for JTX-8064 as a monotherapy and in combination with JTX-4014, Jounce's internal PD-1 inhibitor, or pembrolizumab is currently enrolling patients with advanced solid tumors. Jounce's most advanced product candidate, vopratelimab, is a monoclonal antibody that binds to and activates ICOS, and is currently being studied in the SELECT Phase 2 trial. JTX-4014 is a PD-1 inhibitor intended for combination use in the INNATE and SELECT trials and with Jounce's broader pipeline. Additionally, Jounce exclusively licensed worldwide rights to JTX-1811, a monoclonal antibody targeting CCR8 and designed to selectively deplete T regulatory cells in the tumor microenvironment, to Gilead Sciences, Inc. For more information, please visit
      Diversity and Inclusion StatementJounce strives to create a workplace that reflects the diversity of cancer patients, and where all feel included and valued because of their differences. Actively including people who add to our culture and enhance our values leads to better decisions and outcomes for those we serve - patients, all patients. Beyond our walls, our focus is on addressing inequities in opportunities for STEM education, careers opportunities in Biotech, and access to cancer care.
      Equal Opportunity Employer Jounce Therapeutics is an equal opportunity employer and does not discriminate in its employment decisions on the basis of race, color, national origin, age, physical or mental disability, marital status, religion, creed, sex, or political beliefs. We offer a competitive salary and benefits package. All applicants should be legally entitled to work for any employer in the U.S.

Keywords: Jounce Therapeutics, Inc., Cambridge , Principal Scientist, Discovery, Other , Cambridge, Massachusetts

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