Principal Scientist, Discovery Biology

Company: Versant NewCo
Location: Cambridge
Posted on: June 19, 2022

Job Description:

Principal Scientist, Discovery BiologyNested Therapeutics. Cambridge, MAWe are a Cambridge-based VC-backed stealth biotech focused on discovering and developing the next generation of precision oncology small molecule medicines. We are advancing drug discovery programs based on a platform that combines insights into cancer biology, structural biophysics and innovative chemical biology to identify and characterize novel drivers and druggable protein domains. We are seeking an energetic and scientifically motivated scientist to join the Nested team. The candidate will play a significant role in the development and implementation of our evolving platform approach to discover, characterize, and develop unique small molecule anti-cancer agents for the treatment of targeted patient populations. We seek a highly creative drug discovery scientist with a strong background in the fields of cancer biology, cell biology, chemical biology, chemical genetics, and small molecule drug discovery (with a focus in target identification and validation). This position offers an opportunity to contribute to an innovative multi-disciplinary platform approach in a fast-paced team environment. Responsibilities:Serve as a key biology lead in our platform efforts by independently innovating and executing cell-based strategies that drive platform activities and help establish a robust pipeline of new targets. Independently design, execute and interpret cell based experimental approaches in the target identification/target validation phases including characterizing mechanism of action, understanding target biology, and linking to downstream clinical path. Work closely with neighboring functions (data sciences, structural biology, computational chemistry, etc) as a part of a fast-paced and collaborative platform team. Interpret, present and report research findings at internal meetings Potential to manage and direct the activities of a team of research scientists QualificationsPhD equivalent in Biology or other relevant discipline with 5+ years' experience or equivalent in a research laboratory in an academic and/or industry settingSignificant knowledge of cancer biology, chemical genetics, and experience in small molecule cancer drug discovery Strong foundation in cancer biology and chemical biology techniques essential to driving projects forward such as human cancer cell line culturing, cell-based genetic engineering (RNAi, CRISPR, lentiviral overexpression), flow cytometry, and molecular biology (cloning). Proven track record for striving for high level of innovation and scientific excellenceExcellent interpersonal skills with a proven record of empowering world class science and energizing teamsFlexibility to accommodate to rapidly changing priorities and deadlinesAbility to work in a team-based environmentExcellent oral and written communication skills Interested candidates should submit a CV and cover letter to Careers@nestedtx.comNested Therapeutics is a Cambridge-based VC-backed stealth biotech focused on discovering and developing next generation precision oncology small molecule medicines. We are advancing drug discovery programs based on a platform that combines insights in cancer biology, structural biology, biophysics and chemical biology to identify and characterize novel druggable domains of protein targets.

Keywords: Versant NewCo, Cambridge , Principal Scientist, Discovery Biology, Other , Cambridge, Massachusetts