Research Associate/Sr. RA, Molecular Biology
Company: Clade Therapeutics
Location: Cambridge
Posted on: June 19, 2022
Job Description:
Research Associate/Sr. RA, Molecular BiologyPosition SummaryWe
are seeking a highly motivated and innovative Research
Associate/Senior Research Associate with deep expertise in
molecular biology to support the development of iPSC-based cell
therapies. The individual will have an opportunity to join a
passionate group of scientists and shape the science and culture of
the research group in a tangible way. The ideal candidate will be
technically gifted at the design, generation and testing of novel
gene constructs utilizing the latest in molecular biology and gene
expression approaches. Experience with chimeric antigen receptor
design, homologous recombination and gene editing will enable the
successful candidate to contribute directly to the success of our
therapeutic programs. This position is ideal for an individual who
is entrepreneurial and eager to develop within a collaborative and
supportive team of scientists and engineers.If interested and
qualified, please include Requisition # 2021-18 in the subject line
when emailing resume to: careers@cladetx.comResponsibilities
- Design and generate novel constructs to enable highly effective
cell therapies
- Carefully manage the synthesis and sequencing of gene
constructs by external CROs
- Identify innovative synthetic approaches to enhance our cell
therapies via genetic engineering
- Establish appropriate assays to test novel constructs including
methods to test for expression, genomic integration, and functional
outcomes
- Deliver novel constructs to cells to create novel cell lines
and/or reporter cells
- Collaborate with colleagues to advance our internal
programs
- Analyze and present experimental data to our internal team and
collaborators.
- Proactively recognize and solve technical and scientific issues
to assure high quality data.
- Manage lab reagent inventory for molecular biology and build
out functionality as the lab grows.
- Maintain an electronic lab notebook and contribute to support
documentation Qualifications
- B.S., M.S. in Biology, Immunology, or related field with 2+
years post-degree research experience
- Must possess a deep understanding of molecular cloning
techniques and construct design, including promoter choice, codon
optimization, and viral vector backbones.
- Experience troubleshooting tough to synthesize/clone constructs
via creative design approaches
- Robust knowledge of chimeric antigen receptor design principles
is highly desired
- Experience designing homologous recombination "knock-in"
vectors in combination with gene editing technologies is a
plus
- Experience running assays to test gene expression such as qPCR,
ddPCR, western blotting and/or flow cytometry
- Working knowledge of construct delivery to mammalian cells for
testing of expression and function
- Passionate, self-motivated, and determined to do great
science.
- Highly organized and scientifically rigorous with significant
attention to detail.
- Demonstrated ability to work and think independently. Corporate
Values
- Patients First - Proactively and constructively engage to
deliver results for those in need. "Begin with patient's success in
mind"
- Communication and Respect - Foster open exchange with
colleagues and collaborators. Seek to understand and treat people
with courtesy. "Better together"
- Integrity & Excellence - Act honestly and ethically to seek the
truth. Courageously doing the right thing - take smart risks and
make tough decisions in pursuit of exceptional outcomes. "Get it
done right"If interested and qualified, please include Requisition
# 2021-18 in the subject line when emailing resume to:
careers@cladetx.comClade Therapeutics, Inc. is committed to equal
employment opportunity and non-discrimination for all employees and
qualified applicants without regard to a person's race, gender,
age, religion, national origin, disability, veteran status, sexual
orientation or any characteristic protected under applicable
law.
Keywords: Clade Therapeutics, Cambridge , Research Associate/Sr. RA, Molecular Biology, Other , Cambridge, Massachusetts
Didn't find what you're looking for? Search again!
Loading more jobs...