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Associate Scientist-Bioconjugation and Protein Chemistry

Company: Orum Therapeutics
Location: Cambridge
Posted on: June 19, 2022

Job Description:

Associate Scientist I/IIBioconjugation and Protein ChemistryStart Date: ImmediateLocation: Cambridge, MA -General SummaryOrum Therapeutics is seeking to expand our in-house bioconjugation and protein chemistry capabilities to help advance quality compounds toward the clinic. The successful candidate will have a strong background in chemistry or biochemistry and a passion for driving drug discovery projects from the bench. The primary responsibilities will be working in the laboratory to synthesize, purify, and characterize novel bioconjugates for testing as potential therapeutics. In addition, the candidate will be a member of multidisciplinary project teams, collaborating with stakeholders in medicinal chemistry, antibody engineering, biology, and other functions to set project strategy. This opportunity is well-suited for early career scientists seeking the opportunity to quickly grow into roles of increasing responsibility. Candidates with backgrounds in medicinal chemistry, biochemistry, and related disciplines interested in transitioning into a new field are encouraged to apply. -Principle Duties and Responsibilities

  • Synthesize bioconjugates using established (e,g, lysine-NHS, cysteine-maleimide) chemistries and contribute to the development of new methodologies.
  • Purify bioconjugates by different modes (e.g. SEC, affinity, UF/DF) using benchtop and automated (e.g. AKTA FPLC) methods.
  • Characterize bioconjugates using multiple techniques (e.g. UV/Vis, HPLC, and MS).
  • Present written and oral reports to multidisciplinary teams.
  • Contribute to the build-out and upkeep of an expanding laboratory through maintaining shared equipment, assisting with general laboratory housekeeping in collaboration with our Lab Manager, and developing processes for improving workflow efficiency.Skills, Abilities & Competencies
    • 1-2 years of research experience in a laboratory setting
    • Hands-on experience with preparation, purification, and characterization of therapeutics molecules required
    • Previous hands-on experience with bioconjugation, antibodies and antibody-drug conjugates desired
    • Enthusiasm for collaborating with multidisciplinary teams of chemists, protein engineers, and biologists
    • Proficiency with operating common laboratory equipment and maintaining laboratory infrastructureEducation- BS/MS in chemistry, biochemistry, or a related fieldOrum offers a Core benefits program which includes: medical, dental, short and long term disability, life insurance and a 401k.*U.S. citizens and those authorized to work in the U.S. (green card) are encouraged to apply. We are unable to sponsor at this time.*Candidate must be able to pass a background investigation.*Unable to work with 3rd party candidates or agencies. -To perform this job successfully, an individual must be able to perform each essential duty satisfactorily within the context of the representative work environment and physical demands described above. Likewise, qualifications listed are representative of the knowledge, skills, and abilities required to perform the position's essential functions. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.---Orum Therapeutics is an Equal Opportunity Employer (EOE).

Keywords: Orum Therapeutics, Cambridge , Associate Scientist-Bioconjugation and Protein Chemistry, Other , Cambridge, Massachusetts

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