Scientist, Analytical Science
Company: Orum Therapeutics
Location: Cambridge
Posted on: May 16, 2022
Job Description:
JOB TITLEScientist, Analytical ScienceLocationCambridge,
MACompany OverviewOrum Therapeutics is a global biotech pioneering
the precise delivery of targeted protein degraders and other next
generation ADC payloads to improve the treatment of cancer. The
company's neoDegraders are novel, proprietary payloads for targeted
protein degradation and its Antibody neoDegrader Conjugate (AnDC)
platform generates first-in-class antibody drug conjugates. The
first therapeutic candidates from the AnDC platform are in
development for the treatment of solid tumors and hematologic
cancers. Orum announced the close of a $84 million Series B
financing . The first two oncology assets are expecting IND filing
in mid - 2022 and Q1 2023. Orum is located in Cambridge,
Massachusetts, U.S., and Daejeon, South Korea. For more
information, visit The RoleOrum Therapeutics is seeking to expand
our in-house analytical capabilities to help advance quality
compounds toward the clinic. The successful candidate will have a
strong background in LC-MS antibody/protein characterization or
bioanalytical quantitation and a passion for driving high-impact
projects in the anti-cancer drug discovery space. He/she will
conduct bench-based research focused on sample preparation, LC-MS
and HPLC analytical characterization/quantitation for ADC,
Antibody, small molecule drug, data analysis and report within a
dynamic, enthusiastic, highly interdisciplinary and collaborative
team.Responsibilities
- Perform LC-MS characterization of ADC, antibody and small
molecule drug to support Chemistry discovery and development
including: intact mass analysis, deglycosylation and reduction
LC-MS, DAR measurement, peptide mapping, PTM profiling, native MS,
structural characterization for small molecule drugs.
- Identify metabolites of ADC from in vivo or in vitro samples
with LC-MS technology
- Characterize ADC and antibody using HPLC methodology (SEC, HIC,
IEX, RP etc), plus method development
- Instrument operation, maintenance and troubleshooting for
Thermo Vanquish UHPLC-Orbitrap MS, Waters Acquity UPLC-SQD MS, and
Agilent HPLC
- Prepare samples to be tested by LC-MS and LC-MS/MS from various
sources, i.e., purified protein products, biological matrix
(plasma, serum and tissues, etc)
- Present written and oral reports to multidisciplinary team
- Enter all data into electronic laboratory notebooks and
database on a daily basis, generate weekly summary reports for
management review
- Identify and integrate technologies that improve or expand the
ability to LC-MS and HPLC analysis by working with teammates,
collaborators, vendors, and staying abreast of the literature
- Contribute to the build-out and upkeep of an expanding
laboratory through maintaining shared equipment, assisting with
general laboratory housekeeping, and developing processes for
improving workflow efficiencyRequirements and Qualifications
- Ph. D in Chemistry or Biochemistry or a relevant scientific
discipline with 1+ year experience (postdoc or industry) for
therapeutic protein LC-MS analysis, Master with 3+ year of industry
experience
- Essential to possess technical expertise in the LC-MS analysis
of proteins or small molecules, which may be one from protein or
small molecule characterization, protein bioanalytical quantitation
or proteomics.
- Hands-on experience necessary, including sample preparation
(deglycosylation, reduction, and in-solution/in-gel digestion),
LC-MS operation, basic maintenance and troubleshooting, HPLC (SEC,
HIC, IEX, RP etc)
- Nice to have skills: extraction and enrichment techniques
(Affinity Capture, SPE, Protein Precipitation), CE-SDS, cIEF, DLS,
DSC, SDS-PAGE etc;
- A track record of innovation and scientific rigor, strong
problem solving and troubleshooting skills, and ability to
contribute constructively to discussions
- Goal oriented, organized, capable of prioritizing and working
on multiple projects, and able to help others
- Good verbal and written communication skills
- Enthusiasm for collaborating with multidisciplinary teams of
chemists, protein engineers, and biologists
- Proficiency with operating common laboratory equipment and
maintaining laboratory infrastructure Please send your resume and
cover letter to to apply(Title field: Full Name_Analytical
Scientist) Orum is committed to a workplace in which diversity of
people and ideas are valued and welcomed. Orum provides equal
employment opportunities to all employees and applicants for
employment and prohibits discrimination and harassment of any type
without regard to race, color, religion, age, sex, national origin,
disability status, genetics, protected veteran status, sexual
orientation, gender identity or expression, or any other
characteristic protected by federal, state or local laws. This
policy applies to all terms and conditions of employment, including
recruiting, hiring, placement, promotion, termination, layoff,
recall, transfer, leaves of absence, compensation and
training.
Keywords: Orum Therapeutics, Cambridge , Scientist, Analytical Science, Other , Cambridge, Massachusetts
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