Principal Research Associate, Histology Assay Development, Translational Research
Company: Voyager Therapeutics, Inc.
Location: Cambridge
Posted on: May 16, 2022
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Job Description:
About Voyager
We are Voyager Therapeutics, a pre-clinical stage biotech compelled
by curiosity and powered by persistence. Voyagers are bold
innovators who are energized in unlocking the full potential of AAV
gene therapy employing our TRACER TM capsid discovery platform. Our
resolve is to advance the field of AAV gene therapy, and through
our innovative capsids, we are extending the reach and impact of
our technology to help more patients in need.
Recognizing that we can expand on the experience, innovation, and
outcomes that propel our efforts by working together, we actively
seek diverse views. If you're someone who wants to make discoveries
that change the landscape of medicine for patients, we want you on
our team!
Job Summary
Reporting to the Senior Scientist, the Principal Research Associate
will contribute to Voyager's research team at its facility in
Cambridge, Massachusetts. This is a hands-on position for a person
committed to helping the broader team conduct innovative drug
discovery research in a collaborative environment. We are seeking a
person who is enthusiastic about biomedical research and can work
in close partnership with other scientists and team members. This
is an ideal position for an individual with experience in
immunohistochemistry (IHC), immunofluorescence (IF), and in-situ
hybridization (ISH) assay development. The ideal candidate will
demonstrate thorough knowledge of experimental design and
independent thinking to support multiple programs. The Principal
Research Associate must be a highly motivated individual with the
ability to oversee project timelines and deliverables and interpret
and communicate results.
Key Responsibilities
Develop and perform novel tissue-based staining methodologies
immunohistochemistry (IHC), immunofluorescence (IF), and in-situ
hybridization (ISH) assay development
Subsequent image acquisition and analysis of the stained
tissues
Handle and process fresh frozen and fixed nervous-and peripheral-
tissues from rodents, non-human primates, and human
Contribute to experimental design, planning, and execution of
research projects
Collaborate with project team members and peers to anticipate and
resolve day-to-day issues working in a matrix organizational
structure
Oversee histology infrastructure and enable and improve processes,
workflow, and databases to support research activities
Qualifications
BS with 7+ years or MS with 5+ years relevant industry
experience
Extensive experience with using IHC/ISH automated staining systems
preferably Ventana Discovery Ultra and Leica BondRx
Exhibit excellent oral and written communication skills
Preferred
Knowledge and working experience with the anatomy of brain and
spinal cord of rodents, non-human primates, and human
Experience in image acquisition using; whole slide scanners such as
Olympus VS 200 or Aperio Versa, epifluorescence and confocal
microscopy
Experience in image analysis using Halo or Visiopharm or Defeniens
or Image J
Familiarity with newer histology-based precision profiling
techniques and data analysis, such as in-situ sequencing or MERFISH
or Visium spatial transcriptomics or Nanostring's Digital Spatial
Profiling or Spatial Molecular Imager
Voyager Therapeutics requires all U.S. new hires to be fully
vaccinated for COVID-19 prior to the first date of employment.
Voyager Therapeutics will consider reasonable accommodations as
required by federal, state, and local laws.
Keywords: Voyager Therapeutics, Inc., Cambridge , Principal Research Associate, Histology Assay Development, Translational Research, Other , Cambridge, Massachusetts
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