Principal Research Associate, Histology Assay Development, Translational Research

Company: Voyager Therapeutics, Inc.
Location: Cambridge
Posted on: May 16, 2022

Job Description:

About Voyager

We are Voyager Therapeutics, a pre-clinical stage biotech compelled by curiosity and powered by persistence. Voyagers are bold innovators who are energized in unlocking the full potential of AAV gene therapy employing our TRACER TM capsid discovery platform. Our resolve is to advance the field of AAV gene therapy, and through our innovative capsids, we are extending the reach and impact of our technology to help more patients in need.

Recognizing that we can expand on the experience, innovation, and outcomes that propel our efforts by working together, we actively seek diverse views. If you're someone who wants to make discoveries that change the landscape of medicine for patients, we want you on our team!

Job Summary

Reporting to the Senior Scientist, the Principal Research Associate will contribute to Voyager's research team at its facility in Cambridge, Massachusetts. This is a hands-on position for a person committed to helping the broader team conduct innovative drug discovery research in a collaborative environment. We are seeking a person who is enthusiastic about biomedical research and can work in close partnership with other scientists and team members. This is an ideal position for an individual with experience in immunohistochemistry (IHC), immunofluorescence (IF), and in-situ hybridization (ISH) assay development. The ideal candidate will demonstrate thorough knowledge of experimental design and independent thinking to support multiple programs. The Principal Research Associate must be a highly motivated individual with the ability to oversee project timelines and deliverables and interpret and communicate results.

Key Responsibilities
Develop and perform novel tissue-based staining methodologies immunohistochemistry (IHC), immunofluorescence (IF), and in-situ hybridization (ISH) assay development
Subsequent image acquisition and analysis of the stained tissues
Handle and process fresh frozen and fixed nervous-and peripheral- tissues from rodents, non-human primates, and human
Contribute to experimental design, planning, and execution of research projects
Collaborate with project team members and peers to anticipate and resolve day-to-day issues working in a matrix organizational structure
Oversee histology infrastructure and enable and improve processes, workflow, and databases to support research activities

Qualifications
BS with 7+ years or MS with 5+ years relevant industry experience
Extensive experience with using IHC/ISH automated staining systems preferably Ventana Discovery Ultra and Leica BondRx
Exhibit excellent oral and written communication skills

Preferred
Knowledge and working experience with the anatomy of brain and spinal cord of rodents, non-human primates, and human
Experience in image acquisition using; whole slide scanners such as Olympus VS 200 or Aperio Versa, epifluorescence and confocal microscopy
Experience in image analysis using Halo or Visiopharm or Defeniens or Image J
Familiarity with newer histology-based precision profiling techniques and data analysis, such as in-situ sequencing or MERFISH or Visium spatial transcriptomics or Nanostring's Digital Spatial Profiling or Spatial Molecular Imager

Voyager Therapeutics requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. Voyager Therapeutics will consider reasonable accommodations as required by federal, state, and local laws.

Keywords: Voyager Therapeutics, Inc., Cambridge , Principal Research Associate, Histology Assay Development, Translational Research, Other , Cambridge, Massachusetts