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Research Associate, Stem Cells

Company: QurAlis
Location: Cambridge
Posted on: May 13, 2022

Job Description:

ABOUT THE COMPANY
QurAlis is applying precision medicine to advance a novel therapeutic pipeline for the treatment of amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and other neurodegenerative diseases. Our stem cell technologies can test efficacy of various therapies and provide a transitional bridge to the clinic enabling target validation, discovery, and molecule selection. We are advancing three antisense and small molecule programs addressing sub-forms of ALS that account for most patients. Together with a world-class network of thought leaders, drug developers, and patient advocates, our growing team is at the leading edge of neurodegenerative research and development.

We are honored to have won the Fierce15 and the New England Venture Capital Association's NEVY award for Best Emerging Life Science Company in New England's startup ecosystem. -We are pioneers in neurodegenerative disease biology, stem cell and antisense oligonucleotides (ASO) technology, biomarkers, and small molecule design. -We are honest and empathetic to our patient community, science, colleagues, and ourselves, sharing a common passion to urgently discover new medicines for ALS and FTD. -We represent a diversity of backgrounds and value collaboration. -We believe that success in treating neurodegenerative diseases will be achieved by being precise - targeting the right patients, identifying the right disease mechanism, and carefully developing disease-modifying, clinically meaningful therapies to improve the lives of patients.

Summary of Position

QurAlis is seeking a highly motivated Research Associate to support and execute its cutting-edge stem cell biology models. The Research Associate will work closely with the QurAlis scientific and management teams to perform studies in a high quality and scientifically rigorous fashion.

Primary Job Responsibilities:

Cell line maintenance, expansion, and cryopreservation of human induced pluripotent stem cells (iPSCs)
Differentiation of iPSCs into specialized neurons and glia for target validation and drug discovery efforts
Characterization and quality control of iPSCs and iPSC-derived neurons using routine cellular and biochemical assays (immunofluorescence, imaging assays, microscopy, western blotting, qPCR).
Process, organize, and summarize data using electronic lab notebook. This includes detailed lab records of experiments, cell line tracking and reagent management.
Ability to improve and develop new protocols/new assays and address key questions
Works under minimal supervision for routine activities and moderate supervision for non-routine activities
Assist in maintenance of the cell culture facility/equipment, and the generation and implementation of standard operating procedures
Organize an effective working schedule and prioritize tasks appropriately
Perform other duties and responsibilities as directed.
Must have scheduling flexibility to enable weekend and holiday work rotations

Minimum Qualifications Required

A Bachelor's degree in the biological sciences with 2+ years lab experience or master's degree with 1+ year lab experience
Prior experience with mammalian cell culture is required. Stem cell experience strongly preferred
High performer, willingness and motivation to learn new skills and mastery
Sharp attention to detail and ability to multitask
Strong communication skills including ability to follow written and oral instructions
Ability to interact and collaborate successfully in cross-functional teams
Must be authorized to work legally in the United States.

Keywords: QurAlis, Cambridge , Research Associate, Stem Cells, Other , Cambridge, Massachusetts

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