Scientist, In Vivo Pharmacology

Company: TCR - Therapeutics Inc.
Location: Cambridge
Posted on: May 13, 2022

Job Description:

At TCR - Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access.

We are headquartered in Cambridge, Massachusetts with a clinical manufacturing facility in Rockville, MD. This role will be based in Cambridge, MA.

We are seeking a talented In Vivo Scientist with a strong background in cancer immunotherapy to support the advancement of TCR2's pipeline of targeted TRuC T cell therapies. Reporting to the Sr. Director of Pharmacology you will have extensive hands-on experience with mouse tumor models for immuno-oncology and will apply these skills to develop models tailored to address target and/or indication-specific biology. You are a highly motivated, interactive and creative scientist who will oversee the design and execution of xenograft and syngeneic mouse tumor model studies that will guide lead candidate selection and demonstrate preclinical proof-of-concept for enhancement strategies.

Responsibilities:

Devise and execute tumor model strategies for TRuC T cell programs based on a deep scientific understanding of target & indication biology
Design and engineer tumor models relevant for assessing the efficacy of TRuC T cells bearing a variety of enhancement constructs designed to improve T cell function and overcome tumor immune evasion
Oversee the execution of in vivo pharmacology studies aimed at identifying lead candidates for novel TRuC T cell therapies and selecting optimal enhancements or combinations of enhancements
Collaborate across multiple cross-functional program teams, providing leadership on tumor model selection and development
Analyze, interpret, and present research findings to internal and external audiences

Requirements:

Ph.D.* in biology-related discipline with 1-2 years of post-Ph.D. research experience, in the in vivo evaluation of cancer immunotherapies
Highly proficient in the technical performance of xenogeneic and syngeneic mouse tumor model studies with extensive experience in model development and validation
Proven ability to engineer tumor cell lines to express multiple proteins of interest
Strong understanding of tumor immunology and tumor cell biology
Prior experience with T cell therapies is highly desirable
Excellent oral and written communication skills
Keen attention to detail with excellent organizational and record-keeping skills

*Candidates without a Ph.D. may be considered if they have commensurate experience

Keywords: TCR - Therapeutics Inc., Cambridge , Scientist, In Vivo Pharmacology, Other , Cambridge, Massachusetts