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Principal Scientist, Translational Research

Company: Bristol-Myers Squibb
Location: Cambridge
Posted on: May 12, 2022

Job Description:

At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science. -In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.About Bristol-Myers SquibbBristol-Myers Squibb (BMS) is a global Biopharma company committed to a single mission: to discover, develop, and deliver innovative medicines focused on helping millions of patients around the world in disease areas such as oncology, immunology, hematology, and cardiovascular disease.Join us and make a difference. We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration, and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results.The Mechanisms of Cancer Resistance (MoCR) Thematic Research Center (TRC) in Cambridges Kendall Square is one of the fundamental research and early development engines delivering oncology therapeutics to patients.The scientists at this state-of-the-art R&D site focus on novel targets and pathways for tumors that are refractory to current Immuno-Oncology and Oncology therapies, and implement our discovery platforms across all of our therapeutic focus areas. We partner closely with colleagues in Translational Medicine, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials. Ultimately, our goal is to accelerate the translation of scientific knowledge and insights into the next wave of transformational medicines for cancer patients.Position SummaryThe Principal Scientist will be responsible for creating and executing translational plans for the portfolio of assets within the MoCR TRC. (S)he will design, deliver, and execute biomarker & translational strategies from lead optimization through clinical Proof of Concept (PoC), including creating and running assays for target engagement, pharmacodynamic (PD) biomarkers, and patient selection strategies. (S)he is highly motivated, interactive, and creative and has the ability to work across a highly matrixed organization to advance programs.Detailed Position Responsibilities

  • Work closely with cross-functional groups including Discovery Biology, Pharmacology, and bioinformatics groups and clinical study team to create and execute translational plans including potential pharmacodynamic and predictive biomarkers for development candidates within the MoCR TRC.
  • Oversee the conception and design of experimental medicine studies that confirm mechanism of action, pharmacology, and initial assessments of efficacy through Clinical PoC.
  • Lead a translational sub-team with cross-functional scientists and clinicians and responsible for creating and executing translational plans for the portfolio of assets within MoCR TRC.
  • Independently design and implement translational research studies and clinical biomarker assays utilizing cutting-edge technologies.
  • Accountable for analysis of the data, generating study reports, developing SOPs and all pertinent documentation and responses for assigned programs.
  • Progress translational plans into implementation and execution via internal technical assay execution and/or execution with external CROs.
  • Provide insight into novel ways to incorporate biomarkers into clinical designs to enable early understanding of emerging drug profiles.Desired ExperienceRequired
    • Ph.D. in oncology, immunology, or relevant field, and at least 5 years of industry drug development experience.
    • Understanding of the role of translational research/medicine and clinical biomarkers in drug development.
    • Knowledge and experiences in clinical operations and clinical biomarker discovery and development.
    • Hands-on experience in the design, execution, and generation of clinic-ready translational biomarker assays in oncology.
    • Ability to work independently to design experiments, interpret data, troubleshoot, and suggest next steps.
    • Highly collaborative spirit for working in a matrix environment; attention to detail and self-motivated to perform reproducible experiments.
    • Strong written & verbal communication skills for presenting data and ideas to multiple stakeholders across disciplines.
    • Experience in managing CRO or external collaboration.Preferred
      • Experience in developing in vitro and ex vivo assays to investigate immune function and knowledge of technologies used to assess immune endpoints.
      • Experience in pharmaceutical drug development of multiple therapeutic modalities (e.g. small molecules, antibodies, antibody drug conjugates).Development ValueThis position offers a unique opportunity to be a Translational Research Lead in drug discovery and early clinical development, tackling the biological and clinical challenges that need to be accounted for in assessing disease response. This exciting role will pave the way to further opportunities for professional growth into mentoring, team leadership, and management.Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. -Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. - Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. - This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to . Visitto access our complete Equal Employment Opportunity statement.Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

Keywords: Bristol-Myers Squibb, Cambridge , Principal Scientist, Translational Research, Other , Cambridge, Massachusetts

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