Principal Scientist
Company: Pfizer
Location: Cambridge
Posted on: May 12, 2022
Job Description:
ROLE SUMMARYThe Internal Medicine Research Unit (IMRU) is
seeking a highly talented and motivated scientist to drive
exploration of new pathways and targets in relevant disease areas.
As a key member of the Metabolism and Mass Spectrometry laboratory,
this individual will be focused on the identification and
validation of new targets, and the development of novel compounds
for the treatment of metabolic diseases including cachexia, HFpEF,
hyperinsulinemia and other diseases where dysmetabolic states play
a key pathophysiological role. We are seeking scientists with a
keen interest and deep understanding in metabolism and biological
science that are commensurate with research experience. The
candidate will be involved in drug discovery research projects from
early target identification to drug development, and will thrive in
a multidisciplinary team environment requiring excellent oral and
written communication skills.The successful candidate must
demonstrate:
- Advanced knowledge of the principles, concepts, and practices
in the fields of metabolism, cellular and molecular biology.
- Ability to work collaboratively with subject matter experts to
integrate data from multiple sources (single nucleus, spatial or
bulk RNAseq, proteomics, metabolomics / lipidomics, etc.).
- Innovation and self-motivation, capable of working
independently as well as in the team setting.In addition to a
research seminar, the candidate will give a "chalk talk" presenting
a research plan aimed at advancing understanding of diseases where
dysmetabolic states play a key pathophysiological role. The
candidate will be expected to integrate feedback and execute this
research to identify or validate new targets once hired.ROLE
RESPONSIBILITIES
- Develop proposals for potential new targets based on a
combination of literature and internal/external multi omics data
sets
- Aid in the triage of genome-wide association study hits with
links to hyperinsulinemia, body weight regulation, and related
diseases
- Design and execute experiments to functionally characterize
GWAS hits in relevant in vitro and in vivo models
- Collaborate with scientists across the Research Unit to advance
new targets for hypothesis testing and for establishing portfolio
programs
- Participate in team meetings by presenting experimental plans
and results
- Initiate collaborations with leading academic labs to enable
internal research programs
- Supervise 2+ lab-based colleagues
- Strive to publish scientific and methodological results in high
quality journalsBASIC QUALIFICATIONS
- PhD in Biology or a related scientific field with 5+ years
relevant post-PhD work experience in an academic or
biopharma/biotech setting, utilizing innovative disease model
systems or human data to solve biological problems
- Expertise and demonstrated experience in principles, concepts,
and practices of cellular and molecular biology including
generation and evaluation of in vitro and in vivo disease-relevant
models.
- Working knowledge of cellular metabolism---PREFERRED
QUALIFICATIONS
- Exposure to metabolomics and lipidomics data
- Knowledge of immunology/inflammation pathways is a plusOther
Job Details:
- Eligible for Employee Referral Bonus: YES
- Eligible for Relocation: YESPfizer requires all U.S. new hires
to be fully vaccinated for COVID-19 prior to the first date of
employment. As required by applicable law, Pfizer will consider
requests for Reasonable Accommodations.Sunshine ActPfizer reports
payments and other transfers of value to health care providers as
required by federal and state transparency laws and implementing
regulations. These laws and regulations require Pfizer to provide
government agencies with information such as a health care
provider's name, address and the type of payments or other value
received, generally for public disclosure. Subject to further legal
review and statutory or regulatory clarification, which Pfizer
intends to pursue, reimbursement of recruiting expenses for
licensed physicians may constitute a reportable transfer of value
under the federal transparency law commonly known as the Sunshine
Act. Therefore, if you are a licensed physician who incurs
recruiting expenses as a result of interviewing with Pfizer that we
pay or reimburse, your name, address and the amount of payments
made currently will be reported to the government. If you have
questions regarding this matter, please do not hesitate to contact
your Talent Acquisition representative.EEO & Employment
EligibilityPfizer is committed to equal opportunity in the terms
and conditions of employment for all employees and job applicants
without regard to race, color, religion, sex, sexual orientation,
age, gender identity or gender expression, national origin,
disability or veteran status. Pfizer also complies with all
applicable national, state and local laws governing
nondiscrimination in employment as well as work authorization and
employment eligibility verification requirements of the Immigration
and Nationality Act and IRCA. Pfizer is an E-Verify
employer.Research and Development
Keywords: Pfizer, Cambridge , Principal Scientist, Other , Cambridge, Massachusetts
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