Senior Scientist, Single Cell & Systems Biology

Company: Sanofi
Location: Cambridge
Posted on: May 12, 2022

Job Description:

Position Overview:The Discovery and Validation group in the Single-Cell Biology Cluster, Precision Medicine and Computational Biology at Sanofi is focused on delivering first-in-class medicines to patients by deconstructing the mechanisms of disease into cellular building blocks and advancing first-in-class therapeutics for precision targeting of pathogenic cell types. Our efforts have achieved significant internal and external visibility and media presence.We are seeking a highly competent, independent, proactive, driven and well-organized Senior Scientist to build on our present achievements and ensure our future success. The ideal candidate will derive professional satisfaction from:Generating hypotheses on how pathogenic cell type/state drive diseases (especially in immunological, neurological, and rare disease areas) by leveraging internal and external single-cell data.Applying established single-cell transcriptomic & proteomic methods to understand disease and drug mechanisms.Using analytic tools and workflows to uncover the activity of disease-relevant genes and pathways in pathogenic cell types.Leading projects involving internal experiment design and data analytics as well as outsourcing of established workflows and/or complex follow-up mechanistic assays (organoid, CRISPR, proteomics)Collaborating with academic, industry, and internal partners on method development and disease-focused scientific studies.Leading and contributing to high-profile presentations and publications.S/he should have the ability to creatively lead projects and coordinate scientific activities, summarize and present results, and establish their relevance to key decision points in the drug discovery process. Opportunities to mentor interns, and junior scientists may be available.Qualifications:Ph.D. in Systems Biology, Immunology, Neuroscience or related discipline, with postdoctoral training at a solid academic institution and/or equivalent industry experience (exceptional candidates with the right background and skills may be considered right after Ph.D.)A track record of productivity, innovation and impact (publications, patents)Broad experience with cell-based assays and molecular techniques such as primary cell isolation/culture, multicolor flow cytometry, cell sorting, ELISA, qPRC, RNA and DNA isolation, immunoblot.Extensive hands-on experience and deep knowledge of single-cell experimental and/or analytical workflows (10X, InDrop, SeqWell, CITE/REAP-seq, etc). Ability to use R or python based analytic workflows a definite plus.Excellent communication, organizational, interpersonal and team skills; track record of success working collaboratively across disciplines.What we offer:A combination of start-up mindset and big pharma stability.An academic spirit of curiosity and potential for direct impact on people's lives.An environment fostering individual growth, ensuring visibility and celebrating achievement.Flexible, goal-oriented work schedule, excellent work-life balance, allowing you to thrive both professionally and personally.At Sanofi R&D North America, we deliver meaningful solutions for patients. We transform science into breakthrough, best-in-class and first-in-class medicines and vaccines. We believe in creating a diverse and inclusive workforce - and workplace - which brings together the collective brainpower of over 2,000 colleagues and provides you with an exciting place to grow and develop. We set the bar high, and we deliver. Join us and together we will build on our trusted legacy of breakthroughs for society.Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.As a healthcare company and a vaccine manufacturer, Sanofi has an important responsibility to protect individual and public health. All US based roles require individuals to be fully vaccinated against COVID-19 as part of your job responsibilities.Fully vaccinated, according to the CDC, an individual is considered to be "fully vaccinated" fourteen (14) days after receiving (a) the second dose of the Moderna or Pfizer vaccine, or (b) the single dose of the J&J vaccine. Fully vaccinated, for new Sanofi employees, is to be fully vaccinated 14 DAYS PRIOR TO START DATE. GD-SALI-SAPDNAt Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.PDN-95f06d53-86dd-4d5e-b250-a0ac92bf53d6

Keywords: Sanofi, Cambridge , Senior Scientist, Single Cell & Systems Biology, Other , Cambridge, Massachusetts