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Scientist, IPS ES Differentiation

Company: CRISPR Therapeutics
Location: Cambridge
Posted on: May 11, 2022

Job Description:

Company Overview

CRISPR Therapeutics is a leading gene editing company focused on developing transformative gene-based medicines for serious diseases using its proprietary CRISPR/Cas9 platform. CRISPR/Cas9 is a revolutionary gene editing technology that allows for precise, directed changes to genomic DNA. CRISPR Therapeutics has established a portfolio of therapeutic programs across a broad range of disease areas including hemoglobinopathies, oncology, regenerative medicine, and rare diseases. To accelerate and expand its efforts, CRISPR Therapeutics has established strategic collaborations with leading companies including Bayer, Vertex Pharmaceuticals and ViaCyte, Inc. CRISPR Therapeutics AG is headquartered in Zug, Switzerland, with its wholly-owned U.S. subsidiary, CRISPR Therapeutics, Inc., and R&D operations based in Cambridge, Massachusetts, and business offices in San Francisco, California and London, United Kingdom.

Job Summary

We are seeking a talented scientist to join an exciting, fast growing and well financed new company striving to develop novel cell therapies from ES/IPS cells. The ideal candidate will have significant research experience in gene editing of ES/IPS cells and differentiation. The candidate must be skilled in stem cell biology, molecular biology, and analytical techniques used to characterize gene edited cells and their differentiated populations. This position requires the ability to creatively solve challenging problems, both by working independently as well as part of a team.

Establish robust protocols to generate and scale the differentiation of various specific cell types from stem cells
Design, execute, and interpret multiple experimental workflows including the standard stem cell biology methods
Develop molecular and functional assays in relevant cell types differentiated from iPSCs
Dissect published literature to find novel solutions to cell therapy problems.

Ph.D. (or equivalent degree) in molecular and cell biology, developmental biology, stem cell biology, or related disciplines and 0-3 years of relevant post-doctoral employment experience
Proven expertise in developing human stem cell approaches, applications to unique biological problems, profiling, and assay development
Deep knowledge of human iPSC cell culture, characterization, QC, and differentiation
Proven hands-on experience with a variety cell-based and molecular biology readout technologies, such as RNAseq, FACS, qPCR, immunostaining
Excellent oral and written communication skills
Ability to work independently as well as collaboratively in a results-oriented research team environment
Must possess critical thinking and self-reliance to solve tasks independently
Self-motivated and scientifically rigorous, successful candidate will have outstanding organization and multitasking capability
Candidate must possess flexibility to quickly pivot as projects demand.

CRISPR Therapeutics, Inc. is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law.

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Keywords: CRISPR Therapeutics, Cambridge , Scientist, IPS ES Differentiation, Other , Cambridge, Massachusetts

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