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Research Associate/Sr. Research Associate, T-Cell Process Development

Company: TCR - Therapeutics Inc.
Location: Cambridge
Posted on: January 16, 2022

Job Description:

At TCR - Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access.

We are headquartered in Cambridge, Massachusetts with a clinical manufacturing facility in Rockville, MD.

We are looking for a Research Associate/Sr. Research Associate to join the T Cell Process Development team to work on cutting edge TRuC T cell manufacturing process, and to support regulatory filings. You will report to our Senior Scientist, T Cell Process Development and work closely with the Analytical Development group and other teams as needed. This is an excellent opportunity for career development, working closely with experienced scientists in a fast-paced and highly collaborative environment to support the production and in vitro characterizations of novel autologous and allogeneic TRuC-T cells programs.


  • Perform T cell isolation, enrichment, activation, transduction, expansion and cryopreservation utilizing functionally closed cell systems
  • Perform in-vitro cellular assays involving flow cytometric, molecular and functional characterization of genetically engineered primary T cells
  • Collaborate with the Analytical Development group in improving primary T-cells characterization
  • Contribute to the development and production of TRuC--- T-cells for various pipeline programs and in-vivo animal studies
  • Analyze results and document scientific results for IND enabling studies

    • B.S./M.S. degree in immunology, cell biology or similar discipline with 2+ years of experience in biotech and/or Pharma
    • Experience in analytical assay execution and development, particularly cell based toxicity assays is required and flow cytometry, ELISA, PCR is preferred
    • Experience working with lentiviral and transduction of human T cells along with functionally closed systems are highly desirable. If no experience this is an opportunity to learn!
    • Excellent attention to detail and problem-solving skills, ability to analyze and interpret data.
    • Must be a highly effective collaborator with strong written/verbal communication and interpersonal skills

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Keywords: TCR - Therapeutics Inc., Cambridge , Research Associate/Sr. Research Associate, T-Cell Process Development, Other , Cambridge, Massachusetts

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