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Associate Scientist, Analytical Development, Bioassays

Company: TCR-- Therapeutics Inc.
Location: Cambridge
Posted on: January 16, 2022

Job Description:

At TCR-- Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage cell therapy company pioneering the development of novel T cell therapies by utilizing our TRuC platform. Our lead autologous cell product gavo-cel (TC-210) is being studied in a Phase 1/2 trial for treatment refractory mesothelin-expressing solid tumors. In addition, our emerging and dynamic oncology pipeline focuses on a series of next-generation enhancements, novel targets and an allogeneic platform which may further improve clinical outcomes and broaden patient access.

We are headquartered in Cambridge, Massachusetts with a clinical manufacturing facility in Rockville, MD

We are looking for an Associate Scientist to perform testing of cellular drug products using complex bioassays and participate in T Cell product characterization studies. You will report to our Principal Scientist, Analytical Development and work closely with the Regulatory and T Cell Process Development teams.

Your primary responsibilities will include testing of manufactured T Cells, and characterization of engineered T Cells for product and attribute understanding. Additional activities could include evaluation of new technologies, improving existing assays, and authorship of regulatory documents. The position represents an excellent opportunity for career development, working closely with experienced scientists in a fast-paced and highly collaborative environment.

Responsibilities:

  • Execute a variety of analytical methods, including cell based assays, ELISAs, and flow cytometry.
  • Analyze data, document results, and write corresponding technical reports for product characterization studies.
  • Write protocols and reports for internal and/or regulatory use.
  • Work closely and effectively with CMC stakeholders, including Process Development, Regulatory, and Quality.
  • This is a hands-on position requiring execution of laboratory experiments.

    Requirements:
    • M.S. in biochemistry, chemical engineering, or related discipline with 4+ years relevant industry experience, or B.S. with 5+ years relevant industry experience.
    • Industry experience is required for this position.
    • Experience with analytical assays required, with emphasis on cell and plate-based assays.
    • Experience with flow cytometry, mammalian cell culture, and/or primary human cells a plus.
    • Strong technical writing skills with industry experience writing technical protocols, reports, and procedures is required.
    • Outstanding critical thinking and organizational skills, leadership, and attention to detail.
    • Team-based candidate interested in a fast-paced, exciting, start-up environment!

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Keywords: TCR-- Therapeutics Inc., Cambridge , Associate Scientist, Analytical Development, Bioassays, Other , Cambridge, Massachusetts

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